UNALTERED [H-3] GBR-12935 BINDING AFTER CHRONIC TREATMENT WITH DOPAMINE ACTIVE-DRUGS

被引：64

作者：

ALLARD, P

ERIKSSON, K

ROSS, SB

MARCUSSON, JO

机构：

[1] UMEA UNIV,DEPT GERIATR MED,S-90185 UMEA,SWEDEN

[2] ASTRA RES CTR,DEPT PHARMACOL,RES & DEV LABS,S-15185 SODERTALJE,SWEDEN

来源：

PSYCHOPHARMACOLOGY | 1990年 / 102卷 / 03期

关键词：

[!sup]3[!/sup]H]GBR-12935; Chronic treatment; Dopamine active drugs; Dopamine uptake sites; Rat striatum;

D O I：

10.1007/BF02244092

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rats were injected intraperitoneally with haloperidol 0.5 mg/kg, raclopride 1 mg/kg, bromocriptine 2.5 mg/kg, d-amphetamine 2.5 mg/kg, or cocaine 10 mg/kg twice daily for 21 days. The animals were sacrificed 72 h after last injection. Control rats were injected with saline, following the same schedule. The radioligand [3H]GBR-12935 was used as a presynaptic marker for dopamine neurites. There were no significant differences in [3H]GBR-12935 binding to striatum between drug-treated rats and controls. © 1990 Springer-Verlag.

引用

页码：291 / 294

页数：4

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