EFFECT OF SHORT-TERM ZINC SUPPLEMENTATION ON ZINC AND SELENIUM TISSUE DISTRIBUTION AND SERUM ANTIOXIDANT ENZYMES

被引:14
作者
Skalny, Andrey A. [1 ,2 ]
Tinkov, Alexey A. [2 ,3 ,4 ]
Medvedeva, Yulia S. [5 ]
Alchinova, Irina B. [5 ]
Karganov, Mikhail Y. [5 ]
Skalny, Anatoly V. [2 ,3 ,5 ]
Nikonorov, Alexandr A. [4 ]
机构
[1] Fed Medicobiol Agcy, Fed State Sci Inst Inst Toxicol, St Petersburg 192019, Russia
[2] ANO Ctr Biot Med, Russian Soc Trace Elements Med, Moscow 105064, Russia
[3] Yaroslavl State Univ, Lab Biotechnol & Appl Bioelementol, Yaroslavl 150000, Russia
[4] Orenburg State Med Univ, Dept Biochem, Orenburg 460000, Russia
[5] Inst Gen Pathol & Pathophysiol, Lab Physicochem & Ecol Pathophysiol, Moscow 125315, Russia
关键词
zinc asparaginate; selenium; superoxide dismutase; glutathione peroxidase;
D O I
10.17306/J.AFS.2015.3.28
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Background. A significant association between Zn and Se homeostasis exists. At the same time, data on the influence of zinc supplementation on selenium distribution in organs and tissues seem to be absent. Therefore, the primary objective of the current study is to investigate the influence of zinc asparaginate supplementation on zinc and selenium distribution and serum superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity in Wistar rats. Material and methods. 36 rats were used in the experiment. The duration of the experiment was 7 and 14 days in the first and second series, respectively. The rats in Group I were used as the control ones. Animals in Groups II and III daily obtained zinc asparaginate (ZnA) in the doses of 5 and 15 mg/kg weight, respectively. Zinc and selenium content in liver, kidneys, heart, muscle, serum and hair was assessed using inductively coupled plasma mass spectrometry. Serum SOD and GPx activity was analysed spectrophotometrically using Randox kits. Results. Intragastric administration of zinc asparaginate significantly increased liver, kidney, and serum zinc content without affecting skeletal and cardiac muscle levels. Zinc supplementation also stimulated selenium retention in the rats' organs. Moreover, a signifi cant positive correlation between zinc and selenium content was observed. Finally, zinc asparaginate treatment has been shown to modulate serum GPx but not SOD activity. Conclusion. The obtained data indicate that zinc-induced increase in GPx activity may be mediated through modulation of selenium status. However, future studies are required to estimate the exact mechanisms of zinc and selenium interplay.
引用
收藏
页码:269 / 276
页数:8
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