MSLO, A COMPLEX MOUSE GENE ENCODING MAXI CALCIUM-ACTIVATED POTASSIUM CHANNELS

被引：581
作者：
BUTLER, A
TSUNODA, S
MCCOBB, DP
WEI, A
SALKOFF, L
机构：
[1] WASHINGTON UNIV,SCH MED,DEPT ANAT & NEUROBIOL,ST LOUIS,MO 63110
[2] WASHINGTON UNIV,SCH MED,DEPT GENET,ST LOUIS,MO 63110
来源：
SCIENCE | 1993年 / 261卷 / 5118期
关键词：
D O I：
10.1126/science.7687074
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Complementary DNAs (cDNAs) from mSlo, a gene encoding calcium-activated potassium channels, were isolated from mouse brain and skeletal muscle, sequenced, and expressed in Xenopus oocytes. The mSlo-encoded channel resembled ''maxi'' or BK (high conductance) channel types; single channel conductance was 272 picosiemens with symmetrical potassium concentrations. Whole cell and single channel currents were blocked by charybdotoxin, iberiotoxin, and tetraethylammonium ion. A large number of variant mSlo cDNAs were isolated, indicating that several diverse mammalian BK channel types are produced by a single gene.
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页码：221 / 224
页数：4
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