TYROSINE PHOSPHORYLATION OF A YEAST 40 KDA PROTEIN OCCURS IN RESPONSE TO MATING PHEROMONE

被引：22
作者：
BALLARD, MJ
TYNDALL, WA
SHINGLE, JM
HALL, DJ
WINTER, E
机构：
[1] THOMAS JEFFERSON UNIV,DEPT BIOCHEM & MOLEC BIOL,PHILADELPHIA,PA 19107
[2] THOMAS JEFFERSON UNIV,JEFFESON INST MOLEC MED,PHILADELPHIA,PA 19107
来源：
EMBO JOURNAL | 1991年 / 10卷 / 12期
关键词：
FUS3; MATING PATHWAY; PHOSPHOTYROSINE; SIGNAL TRANSDUCTION; YEAST;
D O I：
10.1002/j.1460-2075.1991.tb04944.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tyrosine phosphorylation of proteins in the yeast Saccharomyces cerevisiae has been examined following exposure to the mating pheromone alpha-factor. When a cells are treated with alpha-factor a protein of approximately 40 kDa molecular weight is tyrosine phosphorylated. This tyrosine phosphorylation response requires an intact signal transduction pathway, is not restricted to a short interval of the cell division cycle, and requires protein synthesis for its maximal accumulation. Mating competent fus3 deletion strains fail to elaborate the phosphotyrosine response. The possibility that FUS3 encodes the 40 kDa protein is discussed.
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页码：3753 / 3758
页数：6
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