STIMULATION OF HUMAN GAMMA-DELTA T-CELLS BY NONPEPTIDIC MYCOBACTERIAL LIGANDS

被引：662
作者：
CONSTANT, P
DAVODEAU, F
PEYRAT, MA
POQUET, Y
PUZO, G
BONNEVILLE, M
FOURNIE, JJ
机构：
[1] CNRS,PHARMACOL & TOXICOL FONDAMENTALES LAB,DEPT 3,118 RTE NARBONNE,F-31062 TOULOUSE,FRANCE
[2] INST BIOL,INSERM,U211,F-44035 NANTES,FRANCE
来源：
SCIENCE | 1994年 / 264卷 / 5156期
关键词：
D O I：
10.1126/science.8146660
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Most human peripheral blood gammadelta T lymphocytes respond to hitherto unidentified mycobacterial antigens. Four ligands from Mycobacterium tuberculosis strain H37Rv that stimulated proliferation of a major human gammadelta T cell subset were isolated and partially characterized. One of these ligands, TUBag4, is a 5' triphosphorylated thymidine-containing compound, to which the three other stimulatory molecules are structurally related. These findings support the hypothesis that some gammadelta T cells recognize nonpeptidic ligands.
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收藏
页码：267 / 270
页数：4
相关论文
共 27 条
[1]   RESIDENT PULMONARY LYMPHOCYTES EXPRESSING THE GAMMA-DELTA T-CELL RECEPTOR [J].
AUGUSTIN, A ;
KUBO, RT ;
SIM, GK .
NATURE, 1989, 340 (6230) :239-241
[2]  
BORN W, 1990, IMMUNOL TODAY, V11, P40
[3]   RECOGNITION OF A PEPTIDE ANTIGEN BY HEAT-SHOCK REACTIVE GAMMA-DELTA-LYMPHOCYTES-T [J].
BORN, W ;
HALL, L ;
DALLAS, A ;
BOYMEL, J ;
SHINNICK, T ;
YOUNG, D ;
BRENNAN, P ;
OBRIEN, R .
SCIENCE, 1990, 249 (4964) :67-69
[4]  
BREITMAIER E, 1987, CARBON 13 NMR SPECTR, P401
[5]  
CONSTANT P, UNPUB
[6]  
DAVODEAU F, 1993, J IMMUNOL, V151, P1214
[7]  
DAVODEAU F, 1993, J BIOL CHEM, V268, P15455
[8]  
DAVODEAU F, UNPUB
[9]   RECOGNITION BY HUMAN V-GAMMA-9/V-DELTA-2 T-CELLS OF A GROEL HOMOLOG ON DAUDI-BURKITT LYMPHOMA-CELLS [J].
FISCH, P ;
MALKOVSKY, M ;
KOVATS, S ;
STURM, E ;
BRAAKMAN, E ;
KLEIN, BS ;
VOSS, SD ;
MORRISSEY, LW ;
DEMARS, R ;
WELCH, WJ ;
BOLHUIS, RLH ;
SONDEL, PM .
SCIENCE, 1990, 250 (4985) :1269-1273
[10]  
FISCH P, 1992, J IMMUNOL, V148, P2315
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