FLOW-CYTOMETRY MEASUREMENT OF NUCLEAR-RNA CONTENT IN UVEAL MELANOMA

被引：4

作者：

CHEN, TC

CHAR, DH

WALDMAN, F

JUSTER, RP

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT OPHTHALMOL,CLIN ONCOL UNIT,POB 0730,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,CELL ANAL LAB,SAN FRANCISCO,CA 94143

[3] UNIV CALIF SAN FRANCISCO,FRANCIS J PROCTOR FDN,SAN FRANCISCO,CA 94143

[4] UNIV CALIF SAN FRANCISCO,DEPT RADIAT ONCOL,SAN FRANCISCO,CA 94143

来源：

OPHTHALMIC RESEARCH | 1990年 / 22卷 / 03期

关键词：

flow cytometry; nuclear RNA; uveal melanoma; prognosis; cell type;

D O I：

10.1159/000267022

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

We retrospectively studied the nuclear RNA content in uveal melanomas with known, long-term follow-up. Thirty patients had spindle cell melanomas, 25 had mixed cell tumors, and 9 had epithelioid cell neoplasms. Epithelioid cell types had a higher nuclear RNA content compared to mixed or spindle cell types (p < 0.05). Using the Cox proportional hazards model, the nuclear RNA content appeared to be an independent prognostic indicator in uveal melanomas, and an increased nuclear RNA content was associated with a worse prognosis (p = 0.001).

引用

页码：187 / 193

页数：7

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