THE ENZYMOLOGY OF APURINIC APYRIMIDINIC ENDONUCLEASES

被引：346
作者：
DOETSCH, PW
CUNNINGHAM, RP
机构：
[1] SUNY ALBANY,DEPT BIOL SCI,ALBANY,NY 12222
[2] EMORY UNIV,SCH MED,DEPT BIOCHEM,ATLANTA,GA 30322
来源：
MUTATION RESEARCH | 1990年 / 236卷 / 2-3期
关键词：
AP endonucleases; AP lyases; Apurinic/apyrimidinic endonucleases; DNA repair; enzymology of;
D O I：
10.1016/0921-8777(90)90004-O
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Studies on the enzymology of apurinic/apyrimidinic (AP) endonucleases from procaryotic and eucaryotic organisms are reviewed. Emphasis will be placed on the enzymes from Escherichia coli from which a considerable portion of our knowledge has been derived. Recent studies on similar enzymes from eucaryotes will be discussed as well. In addition, we will discuss the chemical and physical properties of AP sites and review studies on peptides and acridine derivatives which incise DNA at AP sites. © 1990.
引用
收藏
页码：173 / 201
页数：29
相关论文
共 195 条
[1]  
AKAMEDOV AT, 1982, BIOCHIM BIOPHYS ACTA, V696, P163
[2]   APURINIC ENDONUCLEASES FROM SACCHAROMYCES-CEREVISIAE [J].
ARMEL, PR ;
WALLACE, SS .
NUCLEIC ACIDS RESEARCH, 1978, 5 (09) :3347-3356
[3]   DNA-REPAIR IN SACCHAROMYCES-CEREVISIAE - PURIFICATION AND CHARACTERIZATION OF APURINIC ENDONUCLEASES [J].
ARMEL, PR ;
WALLACE, SS .
JOURNAL OF BACTERIOLOGY, 1984, 160 (03) :895-902
[4]   STUDIES ON ESCHERICHIA-COLI X-RAY ENDONUCLEASE SPECIFICITY - ROLES OF HYDROXYL AND REDUCING RADICALS IN PRODUCTION OF DNA LESIONS [J].
ARMEL, PR ;
STRNISTE, GF ;
WALLACE, SS .
RADIATION RESEARCH, 1977, 69 (02) :328-338
[5]   PURIFICATION AND CHARACTERIZATION OF ESCHERICHIA-COLI ENDONUCLEASE-III FROM THE CLONED NTH GENE [J].
ASAHARA, H ;
WISTORT, PM ;
BANK, JF ;
BAKERIAN, RH ;
CUNNINGHAM, RP .
BIOCHEMISTRY, 1989, 28 (10) :4444-4449
[6]  
BACHETTI S, 1975, BIOCHIM BIOPHYS ACTA, V390, P285
[7]   IMPORTANCE OF THIOLS IN THE REPAIR MECHANISMS OF DNA CONTAINING AP (APURINIC OR APYRIMIDINIC) SITES [J].
BAILLY, V ;
VERLY, WG .
NUCLEIC ACIDS RESEARCH, 1988, 16 (20) :9489-9496
[8]   BACTERIOPHAGE-T4 AND MICROCOCCUS-LUTEUS UV ENDONUCLEASES ARE NOT ENDONUCLEASES BUT BETA-ELIMINATION AND SOMETIMES BETA,DELTA-ELIMINATION CATALYSTS [J].
BAILLY, V ;
SENTE, B ;
VERLY, WG .
BIOCHEMICAL JOURNAL, 1989, 259 (03) :751-759
[9]   THE MULTIPLE ACTIVITIES OF ESCHERICHIA-COLI ENDONUCLEASE-IV AND THE EXTREME LABILITY OF 5'-TERMINAL BASE-FREE DEOXYRIBOSE 5-PHOSPHATES [J].
BAILLY, V ;
VERLY, WG .
BIOCHEMICAL JOURNAL, 1989, 259 (03) :761-768
[10]   THE EXCISION OF AP SITES BY THE 3'-5' EXONUCLEASE ACTIVITY OF THE KLENOW FRAGMENT OF ESCHERICHIA-COLI DNA-POLYMERASE-I [J].
BAILLY, V ;
VERLY, WG .
FEBS LETTERS, 1984, 178 (02) :223-227
12345678910