THE ENZYMOLOGY OF APURINIC APYRIMIDINIC ENDONUCLEASES

被引：345
作者：
DOETSCH, PW
CUNNINGHAM, RP
机构：
[1] SUNY ALBANY,DEPT BIOL SCI,ALBANY,NY 12222
[2] EMORY UNIV,SCH MED,DEPT BIOCHEM,ATLANTA,GA 30322
来源：
MUTATION RESEARCH | 1990年 / 236卷 / 2-3期
关键词：
AP endonucleases; AP lyases; Apurinic/apyrimidinic endonucleases; DNA repair; enzymology of;
D O I：
10.1016/0921-8777(90)90004-O
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Studies on the enzymology of apurinic/apyrimidinic (AP) endonucleases from procaryotic and eucaryotic organisms are reviewed. Emphasis will be placed on the enzymes from Escherichia coli from which a considerable portion of our knowledge has been derived. Recent studies on similar enzymes from eucaryotes will be discussed as well. In addition, we will discuss the chemical and physical properties of AP sites and review studies on peptides and acridine derivatives which incise DNA at AP sites. © 1990.
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页码：173 / 201
页数：29
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