PHYSIOLOGICAL RELEASE OF NITRIC-OXIDE IS DEPENDENT ON THE LEVEL OF VASCULAR TONE

被引：72
作者：
VARGAS, HM
IGNARRO, LJ
CHAUDHURI, G
机构：
[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT OBSTET & GYNECOL,LOS ANGELES,CA 90024
[2] UNIV CALIF LOS ANGELES,SCH MED,DEPT PHARMACOL,LOS ANGELES,CA 90024
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 190卷 / 03期
关键词：
Arterial pressure; N[!sup]G[!/sup]-Methyl-L-arginine; Nitric oxide (NO); Pithed rats;
D O I：
10.1016/0014-2999(90)94204-B
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The presser effect of NG-methyl-L-arginine (NMA) was tested in urethane-anesthetized rats which were untreated (control) or devoid of sympathetic tone. In contrast with controls, the NMA response was attenuated by pithing or ganglionic blockade. In pithed rats, the induction of moderate or intense vasoconstriction with constant phenylephrine infusion restored or augmented, respectively, the NMA pressor response. Our data suggest that vascular tone may physiologically regulate the release of nitric oxide in vivo. © 1990.
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页码：393 / 397
页数：5
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