INHIBITION OF SOLUBLE YEAST MITOCHONDRIAL ATPASE BY ETHIDIUM-BROMIDE

被引：8
作者：
CROSBY, B
BOUTRY, M
GOFFEAU, A
机构：
[1] Laboratoire d'Enzymologie Université de Louvain
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 88卷 / 02期
关键词：
D O I：
10.1016/0006-291X(79)92069-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ethidium-bromide inhibits purified yeast F1. Its inhibition yields non competitive kinetics with ATPMg and ADPMg but is competitive with 2,4 dinitrophenol. In submitochondrial particles, ethidium-bromide is competitive with para-hydroxymercuribenzoate. These data suggest a target for ethidium-bromide located at a site of F1 not involved in the hydrolysis of ATPMg. This non catalytic site also reacts with 2,4 dinitrophenol and with parahydroxymercuribenzoate. © 1979.
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收藏
页码：448 / 455
页数：8
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