Objective: To study the effect of the organic substances on adenosine deaminase (ADA) activity in normal and abnormal cerebrospinal fluid (CSF). Methods: Various concentrations of 2-mercaptopurine, Ame" tycine, Adenosine analogues (Guanine, Thymine) and ATP were tested to see their effect on ADA activity in normal and abnormal CSF. Results: ADA activity in normal and abnormal CSF was remarkably decreased with the increasing of concentrations of substances tested. Conclusion: These effects may have important therapeutic implications.
机构:
Univ Fed Santa Maria, Postgrad Program Pharmaceut Sci, Hlth Sci Ctr, BR-97105900 Santa Maria, RS, BrazilUniv Fed Santa Maria, Postgrad Program Pharmaceut Sci, Hlth Sci Ctr, BR-97105900 Santa Maria, RS, Brazil
Pinheiro, F. V.
Pimentel, V. C.
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Univ Fed Santa Maria, Postgrad Program Pharmaceut Sci, Hlth Sci Ctr, BR-97105900 Santa Maria, RS, BrazilUniv Fed Santa Maria, Postgrad Program Pharmaceut Sci, Hlth Sci Ctr, BR-97105900 Santa Maria, RS, Brazil
Pimentel, V. C.
Moresco, R. N.
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Univ Fed Santa Maria, Postgrad Program Pharmaceut Sci, Hlth Sci Ctr, BR-97105900 Santa Maria, RS, BrazilUniv Fed Santa Maria, Postgrad Program Pharmaceut Sci, Hlth Sci Ctr, BR-97105900 Santa Maria, RS, Brazil
Moresco, R. N.
Moretto, M. B.
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Univ Fed Santa Maria, Postgrad Program Pharmaceut Sci, Hlth Sci Ctr, BR-97105900 Santa Maria, RS, BrazilUniv Fed Santa Maria, Postgrad Program Pharmaceut Sci, Hlth Sci Ctr, BR-97105900 Santa Maria, RS, Brazil
机构:
Hong Kong Childrens Hosp, Dept Pathol, Chem Pathol Lab, Kowloon, Hong Kong, Peoples R China
Princess Margaret Hosp, Dept Pathol, Chem Pathol Lab, Kowloon, Hong Kong, Peoples R ChinaHong Kong Childrens Hosp, Dept Pathol, Chem Pathol Lab, Kowloon, Hong Kong, Peoples R China
Chan, Toby Chun Hei
Chen, Sammy Pak Lam
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Princess Margaret Hosp, Dept Pathol, Chem Pathol Lab, Kowloon, Hong Kong, Peoples R China
Queen Elizabeth Hosp, Dept Pathol, Chem Pathol Lab, Kowloon, Hong Kong, Peoples R ChinaHong Kong Childrens Hosp, Dept Pathol, Chem Pathol Lab, Kowloon, Hong Kong, Peoples R China
Chen, Sammy Pak Lam
Mak, Chloe Miu
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Hong Kong Childrens Hosp, Dept Pathol, Chem Pathol Lab, Kowloon, Hong Kong, Peoples R China
Princess Margaret Hosp, Dept Pathol, Chem Pathol Lab, Kowloon, Hong Kong, Peoples R ChinaHong Kong Childrens Hosp, Dept Pathol, Chem Pathol Lab, Kowloon, Hong Kong, Peoples R China
Mak, Chloe Miu
Ching, Chor Kwan
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Princess Margaret Hosp, Dept Pathol, Chem Pathol Lab, Kowloon, Hong Kong, Peoples R ChinaHong Kong Childrens Hosp, Dept Pathol, Chem Pathol Lab, Kowloon, Hong Kong, Peoples R China
Ching, Chor Kwan
Luk, Kristine Shik
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Princess Margaret Hosp, Dept Pathol, Microbiol Lab, Kowloon, Hong Kong, Peoples R ChinaHong Kong Childrens Hosp, Dept Pathol, Chem Pathol Lab, Kowloon, Hong Kong, Peoples R China
Luk, Kristine Shik
Tsang, Yat Ming
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Princess Margaret Hosp, Dept Pathol, Microbiol Lab, Kowloon, Hong Kong, Peoples R ChinaHong Kong Childrens Hosp, Dept Pathol, Chem Pathol Lab, Kowloon, Hong Kong, Peoples R China
Tsang, Yat Ming
Leung, Daniel Cheuk Wa
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Princess Margaret Hosp, Dept Pathol, Chem Pathol Lab, Kowloon, Hong Kong, Peoples R ChinaHong Kong Childrens Hosp, Dept Pathol, Chem Pathol Lab, Kowloon, Hong Kong, Peoples R China