FATAL FAMILIAL INSOMNIA - NEUROPSYCHOLOGICAL STUDY OF A DISEASE WITH THALAMIC DEGENERATION

被引：32

作者：

GALLASSI, R ^{[1
]}

MORREALE, A ^{[1
]}

MONTAGNA, P ^{[1
]}

GAMBETTI, P ^{[1
]}

LUGARESI, E ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV, INST PATHOL, DIV NEUROPATHOL, CLEVELAND, OH 44106 USA

来源：

CORTEX | 1992年 / 28卷 / 02期

关键词：

D O I：

10.1016/S0010-9452(13)80046-9

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Fatal Familial Insomnia (FFI) is an inherited disease characterized clinically by sleep, autonomic and motor disturbances and pathologically by marked atrophy of thc anterior and dorsomedial nuclei of the thalamus. The neuropsychological study of three cases of FFI showed: (1) a progressive disturbance of attention and vigilance, (2) a memory deficit with lability of mnesic traces and difficulty in manipulation and ordering of events, suggesting an alteration of working memory and (3) a deficit of frontal abilities with impairment in planning and prevision of events but preservation of general intelligence.

引用

页码：175 / 187

页数：13

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