DISTRIBUTION AND ELIMINATION OF INTRAVENOUSLY INJECTED URINARY TRYPSIN-INHIBITOR

被引:40
作者
JONSSONBERLING, BM [1 ]
OHLSSON, K [1 ]
机构
[1] UNIV LUND,MALMO GEN HOSP,DEPT ANAESTHESIOL,S-21401 MALMO,SWEDEN
关键词
KIDNEY; PROTEASE INHIBITOR; TURNOVER;
D O I
10.3109/00365519109104564
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Elimination of human urinary trypsin inhibitor (UTI) after intravenous injection of I-125-labelled UTI was followed by serial plasma and urine samples in three male volunteers. The plasma half-life of (IUTI)-I-125 during 0-3 h after injection was 33 min and during the following 4 hours the half-life was 2 hours. Free, biologically active inhibitor was found in the urine during the first four hours after injection. Most of the radioactivity in the urine, however, corresponded to free I-125 probably released during the degradation of UTI in the kidney. The distribution of UTI was studied after injection of (IUTI)-I-125 in rats by measurement of radioactivity in excised organs. Fifteen min after the injection 44% of the radioactivity was found in the kidneys and 9% in the liver, implying that the kidneys are the primary site of UTI metabolism.
引用
收藏
页码:549 / 557
页数:9
相关论文
共 22 条
[1]   HUMAN URINARY PROTEINASE-INHIBITOR - INHIBITORY PROPERTIES AND INTERACTION WITH BOVINE TRYPSIN [J].
BALDUYCK, M ;
DAVRIL, M ;
MIZON, C ;
SMYRLAKI, M ;
HAYEM, A ;
MIZON, J .
BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 1985, 366 (01) :9-14
[2]  
DILLARD GHL, 1950, J LAB CLIN MED, V36, P266
[3]   STUDIES ON PANCREATIC SECRETORY TRYPSIN-INHIBITOR IN PLASMA AND ITS COMPLEX WITH TRYPSIN INVIVO AND INVITRO [J].
EDDELAND, A ;
OHLSSON, K .
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1978, 38 (06) :507-515
[4]  
FAARVANG HJ, 1959, ACTA ENDOCRINOL-COP, V31, P117
[5]  
FRAKER PJ, 1978, BIOCHEM BIOPH RES CO, V80, P849, DOI 10.1016/0006-291X(78)91322-0
[6]   STUDIES ON THE INTERACTION BETWEEN LEUKOCYTE ELASTASE, ANTILEUKOPROTEINASE AND THE PLASMA PROTEINASE-INHIBITORS ALPHA-1-PROTEINASE INHIBITOR AND ALPHA-2-MACROGLOBULIN [J].
FRYKSMARK, U ;
OHLSSON, K ;
ROSENGREN, M ;
TEGNER, H .
HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1983, 364 (07) :793-800
[7]  
GOSSET D, 1988, PRESSE MED, V17, P329
[8]   PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY [J].
GREENWOOD, FC ;
HUNTER, WM .
BIOCHEMICAL JOURNAL, 1963, 89 (01) :114-&
[9]   HUMAN GRANULOCYTE ELASTASE IS INHIBITED BY THE URINARY TRYPSIN-INHIBITOR [J].
JONSSON, BM ;
LOFFLER, C ;
OHLSSON, K .
HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1982, 363 (10) :1167-1175
[10]  
JOSSON BM, 1984, HOPPESEYLERS Z PHYSL, V365, P1403