THE 3-D STRUCTURE OF HIV-1 PROTEINASE AND THE DESIGN OF ANTIVIRAL AGENTS FOR THE TREATMENT OF AIDS

被引：85
作者：
BLUNDELL, TL
LAPATTO, R
WILDERSPIN, AF
HEMMINGS, AM
HOBART, PM
DANLEY, DE
WHITTLE, PJ
机构：
[1] PFIZER INC,GROTON,CT 06340
[2] PFIZER LTD,SANDWICH CT13 9NJ,KENT,ENGLAND
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1990年 / 15卷 / 11期
关键词：
D O I：
10.1016/0968-0004(90)90280-O
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A proteinase is essential for replication of HIV. Cloning and chemical synthesis have provided a sufficient supply of HIV-1 proteinase for the determination of its three-dimensional structure. Analogies between the structures of HIV-1 proteinase and the mammalian enzyme renin, which is involved in the control of blood pressure, have given important clues concerning the design of specific inhibitors that have antiviral activity. © 1990.
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收藏
页码：425 / 430
页数：6
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