ACCUMULATION OF PHENOTHIAZINE TRANQUILIZERS IN RAT BRAIN AND PLASMA AFTER REPEATED DOSAGE

被引：40
作者：
MAHJU, MA
MAICKEL, RP
机构：
[1] Laboratory of Psychopharmacology, Departments of Pharmacology and Psychology, Indiana University, Bloomington
来源：
BIOCHEMICAL PHARMACOLOGY | 1969年 / 18卷 / 12期
关键词：
D O I：
10.1016/0006-2952(69)90178-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
After a single i.p. dose to rats, chlorpromazine, fluphenazine, promazine, triflupromazine and trimeprazine achieve brain/plasma ratios > 1, with half-lives in brain and plasma of < 10 hr. After five doses at 12-hr intervals, brain/plasma ratios of all compounds, except triflupromazine, are greater than after a single dose, due to accumulation in the brain. Triflupromazine appears to reach a maximum limit in the brain at about 11-12 μg/g. The half-lives of promazine and trimeprazine in brain and plasma are greater after five doses than after a single dose, while those of chlorpromazine, fluphenazine and triflupromazine are essentially the same after one or five doses. © 1969.
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页码：2701 / &
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