A NOVEL AMINO PROTECTION DEPROTECTION PROCEDURE AND ITS APPLICATION IN SOLID-PHASE PEPTIDE-SYNTHESIS

被引:23
作者
BYCROFT, BW [1 ]
CHAN, WC [1 ]
CHHABRA, SR [1 ]
TEESDALESPITTLE, PH [1 ]
HARDY, PM [1 ]
机构
[1] UNIV EXETER,CHEM,EXETER EX4 4RJ,DEVON,ENGLAND
关键词
D O I
10.1039/c39930000776
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
N-4,4-Dimethyl-2,6-dioxocyclohexylidenemethyl (Dcm) amino acids are readily prepared and the protecting group can be removed with hydrazine at room temperature; their potential in solid phase peptide synthesis is illustrated.
引用
收藏
页码:776 / 777
页数:2
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