A DEVELOPMENTALLY REGULATED GENE OF ECHINOCOCCUS-GRANULOSUS CODES FOR 15.5-KILODALTON POLYPEPTIDE RELATED TO FATTY-ACID BINDING-PROTEINS

被引：58
作者：
ESTEVES, A
DALLAGIOVANNA, B
EHRLICH, R
机构：
[1] Sección Bioquimica, Facultad de Ciencias, Universidad de la Republica, Montevideo
来源：
MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1993年 / 58卷 / 02期
关键词：
ECHINOCOCCUS-GRANULOSUS; DEVELOPMENT; MOLECULAR MARKER; FATTY ACID BINDING PROTEIN;
D O I：
10.1016/0166-6851(93)90043-W
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A stage-specific expressed gene has been isolated from a cDNA expression library of Echinococcus granulosus protoscolices. The isolated clone contains the complete coding sequence. The corresponding protein (EgDf1) has a molecular weight of 15.5 kDa and is expressed at the tegumental level in the protoscolices, being undetectable in the germinal layer of the metacestode. This protein shares an important homology with a family of low-molecular weight proteins involved in the binding of hydrophobic ligands. This family includes a protein of Schistosoma mansoni (Sm 14) that has immunoprotective activity in rodents. Histochemical and metabolic data already reported for E. granulosus suggest that EgDf1 could be a molecular marker for early events in the process of protoscolex differentiation.
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页码：215 / 222
页数：8
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