IGF-I BINDING AND IGF-I EXPRESSION IN REGENERATING MUSCLE OF NORMAL AND HYPOPHYSECTOMIZED RATS

被引:34
作者
JENNISCHE, E
MATEJKA, GL
机构
[1] Department of Histology, University of Goteborg, Gotebort
来源
ACTA PHYSIOLOGICA SCANDINAVICA | 1992年 / 146卷 / 01期
关键词
AUTORADIOGRAPHY; DIGOXIGENIN LABELING; IGF-I BINDING; INSITU HYBRIDIZATION; INSULIN-LIKE GROWTH FACTOR-I; MUSCLE REGENERATION;
D O I
10.1111/j.1748-1716.1992.tb09395.x
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Binding of iodinated IGF-I to tissue sections from regenerating muscle was studied by autoradiography in normal and in hypophysectomized rats. Binding of IGF-I was low in control muscle in both groups of animals, but increased transiently about 10-fold during regeneration after injury. Maximal binding occurred later in hypophysectomized rats than in control rats, and there was also a slower regeneration process in these animals. IGF-I, as demonstrated by immunohistochemistry, and IGF-I mRNA, as demonstrated by in situ hybridization, were expressed by the regenerating muscle cells in both groups of animals. It is concluded that locally produced IGF-I is the most likely ligand for IGF-I receptors during muscle regeneration.
引用
收藏
页码:79 / 86
页数:8
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