Potential Activity of S100B Level towards Metabolic Syndrome in Obese Children

Paediatric obesity prevalence has increased significantly in developing countries recently followed by increased rates of associated complications such as paediatric metabolic syndrome. Adipose tissue is a good source of S100B which has been linked lately to metabolic syndrome, moreover to insulin insensitivity. This case control study has been designed to evaluate the significance of S100B as an early predictor for metabolic syndrome in obese children and to study its relation to the different parameters of the disease. Forty obese children were enrolled as cases group, out of them 17 had the full metabolic criteria and thirty healthy non obese children of matched age and sex served as control group.Serum S100B level was estimated by ELISA. Children's anthroponnetncs measures', blood pressure, fasting blood glucose, and lipid profile were assessed. Significant difference has been detected between the two groups in serum S100B (p value <0.001). A positive significant correlation has been recorded between systolic blood pressure, TG level and 5100B level (P value <.001). While a significant negative correlation was documented between HDL level and 5100B level. In conclusion, 5100B is considered as an important influential factor in clinical studies of metabolic syndrome.