EFFECTS OF CHOLERA TOXIN AND 5'-GUANYLYLIMIDODIPHOSPHATE ON HUMAN SPERMATOZOAL ADENYLATE-CYCLASE ACTIVITY

被引:32
作者
CHENG, CY
BOETTCHER, B
机构
[1] Department of Biological Sciences, The University of Newcastle
关键词
D O I
10.1016/0006-291X(79)90574-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effects of cholera toxin and 5′-guanylylimidodiphosphate (Gpp(NH)p) on human spermatozoal adenylate cyclase activity were tested. Cholera toxin had no demonstrable effect on adenylate cyclase activity in human spermatozoa at concentrations between 5 and 20 μg/ml, whether the toxin was preincubated with intact spermatozoa between 5 min and 5 h prior the adenylate cyclase assay, or was added to lysed spermatozoa, where the adenylate cyclase would be accessible to the toxin. In contrast, Gpp(NH)p at concentrations between 10 and 100 μM was effective in activating human spermatozoal adenylate cyclase activity. © 1979.
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页码:1 / 9
页数:9
相关论文
共 22 条
[1]  
Casillas E., 1975, HDB PHYSL 7, V5, P453
[2]   ACTIVATION OF MONKEY SPERMATOZOAL ADENYL CYCLASE BY THYROXINE AND TRIIODOTHYRONINE [J].
CASILLAS, ER ;
HOSKINS, DD .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1970, 40 (02) :255-&
[3]   ADENYL CYCLASE ACTIVITY AND CYCLIC 3', 5'-AMP CONTENT OF EJACULATED MONKEY SPERMATOZOA [J].
CASILLAS, ER ;
HOSKINS, DD .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1971, 147 (01) :148-&
[4]  
CASILLAS ER, 1978, FED PROC, V37, P1688
[5]  
DELUCA HF, 1972, MANOMETRIC BIOCH TEC, P146
[6]  
FINKELSTEIN RA, 1973, CRC CRIT R MICROBIOL, V2, P553
[7]   CHARACTERIZATION OF SEA-URCHIN SPERM ADENYLATE-CYCLASE [J].
GARBERS, DL .
BIOLOGY OF REPRODUCTION, 1977, 16 (03) :377-384
[8]  
Gill D M, 1977, Adv Cyclic Nucleotide Res, V8, P85
[9]  
GILL DM, 1975, J BIOL CHEM, V250, P6424
[10]  
GRAY JP, 1971, FED PROC, V30, P1267