Up Growth Effect of Cetyltrimethyl Ammonium Bromide with Carbon Paste Electrode for the Electrochemical Determination of Allopurinol and Its Biological Activities

被引：0
|
作者：
Teradale, Amit B. [1 ,2 ,3 ]
Lamani, Shekappa D. [3 ]
Das, Swastika N. [1 ,2 ]
机构：
[1] BLDEA, Dept Chem, Coll Engn & Technol, Vijayapur 586103, Karnataka, India
[2] Visvesvaraya Technol Univ, Belagavi 586103, Karnataka, India
[3] BLDEA, Dept Chem, SB Arts & KCP Sci Coll, Vijayapur 586103, Karnataka, India
来源：
ANALYTICAL & BIOANALYTICAL ELECTROCHEMISTRY | 2016年 / 8卷 / 07期
关键词：
Allopurinol; Surfactant effect; Electrochemical detection; Drug monitoring; Carbon paste electrode;
D O I：
暂无
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
A stable sensor for the determination of allopurinol (AP) was upgrade by effect of surfactant cetyltrimethyl ammonium bromide (CTAB) with running phosphate buffer solution (pH=3.0) at a carbon paste electrode (CPE). A sensitive electrochemical method was improved distinctly in the presence of low concentration of CTAB, the oxidation peak current signifying that CTAB exhibits noticeable enhancement effect to the determination of AP as well as under optimal conditions the linear sweep voltammetry response to AP has a linear concentration over the range from 0.6 mu M to 60.0 mu M, with limit of detection and quantification 97.2 nM and 0.324 mu M respectively. This constructed voltammetry sensor was successfully applied to determination of AP in the human serum sample, urine sample and tablet. Finally this was shown to be sensitive and efficient.
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页码：814 / 829
页数：16
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