MEMBRANE-LIPIDS OF MYCOPLASMA-FERMENTANS

被引：10

作者：

SALMAN, M

DEUTSCH, I

TARSHIS, M

NAOT, Y

ROTTEM, S

机构：

[1] HEBREW UNIV JERUSALEM,HADASSAH MED CTR,DEPT MEMBRANE & ULTRASTRUCT RES,IL-91120 JERUSALEM,ISRAEL

[2] HEBREW UNIV JERUSALEM,HADASSAH MED CTR,DEPT PHARMACEUT CHEM,IL-91120 JERUSALEM,ISRAEL

[3] TECHNION ISRAEL INST TECHNOL,FAC MED,DEPT IMMUNOL,HAIFA,ISRAEL

来源：

FEMS MICROBIOLOGY LETTERS | 1994年 / 123卷 / 03期

关键词：

MYCOPLASMA FERMENTANS; AIDS; MEMBRANE LIPIDS; FUSION;

D O I：

10.1111/j.1574-6968.1994.tb07233.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Membranes of Mycoplasma fermentans, incognitus strain, were isolated by, a combination of osmotic lysis and sonication. Analysis of membrane lipids revealed, in addition to free and esterified cholesterol, six major polar lipids dominated by a de novo synthesized compound (compound X), which accounts for 64% of the total lipid phosphorus. Compound X was labeled by palmitate, but not by oleate. Mass spectrometry and gas liquid chromatography analyses of compound X revealed two molecular species with molecular masses of 1048 and 1076 representing, a dipalmitoyl- and a stearoyl-palmitoyl-glycerodiphosphatidylcholine. Compound X has the ability to stimulate human monocytes to secret TNF alpha and to enhance the fusion of small unilamellar vesicles with MOLT-3 lymphocytes.

引用

页码：255 / 260

页数：6

共 16 条

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