TARGETED GENE REPLACEMENT - RESEARCHERS CAN NOW CREATE MICE BEARING ANY CHOSEN MUTATIONS IN ANY KNOWN GENE - THE TECHNOLOGY IS REVOLUTIONIZING THE STUDY OF MAMMALIAN BIOLOGY

被引:147
作者
CAPECCHI, MR
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D O I
10.1038/scientificamerican0394-52
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
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页码:52 / 59
页数:8
相关论文
共 3 条
[1]   THE NEW MOUSE GENETICS - ALTERING THE GENOME BY GENE TARGETING [J].
CAPECCHI, MR .
TRENDS IN GENETICS, 1989, 5 (03) :70-76
[2]   ALTERING THE GENOME BY HOMOLOGOUS RECOMBINATION [J].
CAPECCHI, MR .
SCIENCE, 1989, 244 (4910) :1288-1292
[3]   REGIONALLY RESTRICTED DEVELOPMENTAL DEFECTS RESULTING FROM TARGETED DISRUPTION OF THE MOUSE HOMEOBOX GENE HOX-1.5 [J].
CHISAKA, O ;
CAPECCHI, MR .
NATURE, 1991, 350 (6318) :473-479