TARGETED GENE REPLACEMENT - RESEARCHERS CAN NOW CREATE MICE BEARING ANY CHOSEN MUTATIONS IN ANY KNOWN GENE - THE TECHNOLOGY IS REVOLUTIONIZING THE STUDY OF MAMMALIAN BIOLOGY

被引：147
作者：
CAPECCHI, MR
机构：
来源：
SCIENTIFIC AMERICAN | 1994年 / 270卷 / 03期
关键词：
D O I：
10.1038/scientificamerican0394-52
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
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页码：52 / 59
页数：8
相关论文
共 3 条
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[2]   ALTERING THE GENOME BY HOMOLOGOUS RECOMBINATION [J].
CAPECCHI, MR .
SCIENCE, 1989, 244 (4910) :1288-1292
[3]   REGIONALLY RESTRICTED DEVELOPMENTAL DEFECTS RESULTING FROM TARGETED DISRUPTION OF THE MOUSE HOMEOBOX GENE HOX-1.5 [J].
CHISAKA, O ;
CAPECCHI, MR .
NATURE, 1991, 350 (6318) :473-479
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