DYNAMIC KINETIC RESOLUTION

被引：374

作者：

WARD, RS

机构：

[1] Chemistry Department, University of Wales Swansea, Swansea, SA2 8PP, Singleton Park

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 07期

关键词：

D O I：

10.1016/0957-4166(95)00179-S

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The equilibration of a mixture of enantiomers or diastereoisomers prior to or during kinetic resolution permits the isolation of a single isomer of one product in >50% yield. Examples of such processes involving both enantioselective and diastereoselective reactions are discussed. In some cases highly efficient processes are available, yielding, for example, cyanohydrin acetates and alpha-substituted carboxylic acid derivatives in high yield and with high e.e. and d.e. respectively.

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页码：1475 / 1490

页数：16

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