EXPRESSION OF ELECTROSTATIC BINDING COOPERATIVITY IN THE RECOGNITION OF CELL-WALL PEPTIDE ANALOGS BY VANCOMYCIN GROUP ANTIBIOTICS

被引：38

作者：

GROVES, P ^{[1
]}

SEARLE, MS ^{[1
]}

WESTWELL, MS ^{[1
]}

WILLIAMS, DH ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,CAMBRIDGE CTR MOLEC RECOGNIT,CHEM LABS,CAMBRIDGE CB2 1EW,CAMBS,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 13期

关键词：

D O I：

10.1039/c39940001519

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The strength of the binding interaction of the carboxylate group of peptide cell-wall analogues with ristocetin A is shown, by H-1 NMR studies of hydrogen bonded NHs, to increase towards a limiting value as the number of interactions on the same ligand template increases; the carboxylate electrostatic binding energy appears to reflect the whole set of linked weak interactions as a cooperative unit, and this cooperative effect is distinct from the classical chelate effect.

引用

页码：1519 / 1520

页数：2

共 9 条

[1] ON THE ATTRIBUTION AND ADDITIVITY OF BINDING-ENERGIES [J].

JENCKS, WP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (07) :4046-4050

[2]

JENCKS WP, 1975, ADV ENZYMOL RAMB, V43, P219

[3] THERMOCHEMISTRY OF THE INTERACTION BETWEEN PEPTIDES AND VANCOMYCIN OR RISTOCETIN [J].

RODRIGUEZTEBAR, A ;

VAZQUEZ, D ;

VELAZQUEZ, JLP ;

LAYNEZ, J ;

WADSO, I .

JOURNAL OF ANTIBIOTICS, 1986, 39 (11) :1578-1583

[4] PARTITIONING OF FREE-ENERGY CONTRIBUTIONS IN THE ESTIMATION OF BINDING CONSTANTS - RESIDUAL MOTIONS AND CONSEQUENCES FOR AMIDE-AMIDE HYDROGEN-BOND STRENGTHS [J].

SEARLE, MS ;

WILLIAMS, DH ;

GERHARD, U .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (27) :10697-10704

[5]

SEARLE MS, UNPUB

[6] TOWARD AN ESTIMATION OF BINDING CONSTANTS IN AQUEOUS-SOLUTION - STUDIES OF ASSOCIATIONS OF VANCOMYCIN GROUP ANTIBIOTICS [J].

WILLIAMS, DH ;

SEARLE, MS ;

MACKAY, JP ;

GERHARD, U ;

MAPLESTONE, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (04) :1172-1178

[7] TOWARDS A SEMIQUANTITATIVE DESCRIPTION OF A BIMOLECULAR ASSOCIATION INVOLVING WEAK-INTERACTIONS IN AQUEOUS-SOLUTION [J].

WILLIAMS, DH ;

SEARLE, MS ;

WESTWELL, MS ;

GERHARD, U ;

HOLROYD, SE .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 1993, 345 (1674) :11-21

[8] TOWARD THE SEMIQUANTITATIVE ESTIMATION OF BINDING CONSTANTS - GUIDES FOR PEPTIDE PEPTIDE BINDING IN AQUEOUS-SOLUTION [J].

WILLIAMS, DH ;

COX, JPL ;

DOIG, AJ ;

GARDNER, M ;

GERHARD, U ;

KAYE, PT ;

LAL, AR ;

NICHOLLS, IA ;

SALTER, CJ ;

MITCHELL, RC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (18) :7020-7030

[9] H-1-NMR STUDIES OF THE STRUCTURE OF RISTOCETIN-A AND OF ITS COMPLEXES WITH BACTERIAL-CELL WALL ANALOGS IN AQUEOUS-SOLUTION [J].

WILLIAMSON, MP ;

WILLIAMS, DH .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1985, (05) :949-956

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