CHEMOTHERAPY INDUCED CHANGES IN WILMS TUMOR: AN INSTITUTIONAL EXPERIENCE

Title: Chemotherapy induced changes in Wilms tumor: An institutional experience 20 cases of wilms tumor were treated with SIOP protocol using preoperative chemotherapy with vincristine and actinomycin D, the response of the tumor by decrease in size was assessed by imaging and histopathological response was also assessed. 10 cases were of wilms were treated using the NWTS protocol with upfront nephrectomy and used as controls. Gross size reduction was seen with SIOP protocol and significant response of epithelial and stromal elements were noted, as well as blastemal nodules. Diffuse anaplasia did not respond to chemotherapy. This evaluation helps to define the susceptibility of different elements in wilms tumor to chemotherapy.