REGULATION OF GENE-EXPRESSION IN ONCOGENICALLY TRANSFORMED-CELLS

被引：10
作者：
DEHBI, M
BEDARD, PA
机构：
[1] Département de biochimie, Université de Montréal, Québec
来源：
BIOCHEMISTRY AND CELL BIOLOGY | 1992年 / 70卷 / 10-11期
关键词：
ONCOGENES; TRANSCRIPTION FACTORS; TRANSFORMATION; PP60V-SRC;
D O I：
10.1139/o92-142
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Several genes expressed in response to growth factors are also regulated aberrantly in oncogenically transformed cells. The constitutive expression of genes encoding extracellular proteases, transcription factors, and cytokines is often correlated with cell transformation. In several instances, the uncontrolled expression of these genes is the result of transcriptional activation. Therefore, much attention has been devoted to the study of promoter function in transformed cells. We now review the results of recent investigations on transformation-dependent gene expression. The activation of several transcription factors in oncogenically-transformed cells is described. Results regarding the regulation of promoters through PRD II/kappaB are presented for cells transformed by a variety of oncogenes. Finally, we discuss the significance of transcription factor activation in the process of cell transformation.
引用
收藏
页码：980 / 997
页数：18
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