EFFECT OF OCCUPATIONAL LEAD-EXPOSURE ON SERUM 1,25-DIHYDROXYVITAMIN-D LEVELS

被引：18

作者：

MASON, HJ ^{[1
]}

SOMERVAILLE, LJ ^{[1
]}

WRIGHT, AL ^{[1
]}

CHETTLE, DR ^{[1
]}

SCOTT, MC ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,SCH PHYS & SPACE RES,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1990年 / 9卷 / 01期

关键词：

D O I：

10.1177/096032719000900107

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The effects of lead exposure on serum 1,25-dihydroxyvitamin D levels and calcium homeostasis have been studied in 63 males occupationally exposed to the metal in the UK. The exposure indices used were blood lead, reflecting short-term exposure, and an in vivo X-ray fluorescence measurement of tibia lead which reflects cumulative lead exposure. Serum 1,25-dihydroxyvitamin D levels were higher than those in a referent population, who were non-occupationally exposed to lead, and were correlated with both blood lead and tibia lead. Multiple regression analysis suggested that blood lead was the variable responsible for the increase in serum 1,25-dihydroxyvitamin D. There were no other abnormalities in calcium metabolism associated with the degree of lead exposure. © 1990, Sage Publications. All rights reserved.

引用

页码：29 / 34

页数：6

共 32 条

[11]

GOERING PL, 1984, J PHARMACOL EXP THER, V231, P66

[12] EFFECTS OF ELEVATED LEAD AND CADMIUM BURDENS ON RENAL-FUNCTION AND CALCIUM-METABOLISM [J].

GREENBERG, A ;

PARKINSON, DK ;

FETTEROLF, DE ;

PUSCHETT, JB ;

ELLIS, KJ ;

WIELOPOLSKI, L ;

VASWANI, AN ;

COHN, SH ;

LANDRIGAN, PJ .

ARCHIVES OF ENVIRONMENTAL HEALTH, 1986, 41 (02) :69-76

[13] SATURNINE GOUT - A REVIEW OF 42 PATIENTS [J].

HALLA, JT ;

BALL, GV .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 1982, 11 (03) :307-314

[14] LOCALIZATION OF 25-HYDROXYVITAMIN-D3 1-ALPHA-HYDROXYLASE AND 24-HYDROXYLASE ALONG THE RAT NEPHRON [J].

KAWASHIMA, H ;

TORIKAI, S ;

KUROKAWA, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (02) :1199-1203

[15]

MAHAFFEY KR, 1979, FED PROC, V38, P384

[16] NEPHROPATHY IN CHRONIC LEAD POISONING [J].

MORGAN, JM ;

HARTLEY, MW ;

MILLER, RE .

ARCHIVES OF INTERNAL MEDICINE, 1966, 118 (01) :17-+

[17] EFFECTS OF LEAD INCLUSION-BODIES ON SUBCELLULAR-DISTRIBUTION OF LEAD IN RAT-KIDNEY - THE RELATIONSHIP TO MITOCHONDRIAL-FUNCTION [J].

OSKARSSON, A ;

FOWLER, BA .

EXPERIMENTAL AND MOLECULAR PATHOLOGY, 1985, 43 (03) :397-408

[18] BLOOD LEAD CONCENTRATION, BLOOD-PRESSURE, AND RENAL-FUNCTION [J].

POCOCK, SJ ;

SHAPER, AG ;

ASHBY, D ;

DELVES, T ;

WHITEHEAD, TP .

BRITISH MEDICAL JOURNAL, 1984, 289 (6449) :872-874

[19] CELLULAR-METABOLISM OF LEAD - A KINETIC-ANALYSIS IN THE ISOLATED RAT HEPATOCYTE [J].

POUNDS, JG ;

WRIGHT, R ;

KODELL, RL .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1982, 66 (01) :88-101

[20] EFFECT OF LEAD ON CALCIUM HOMEOSTASIS IN THE ISOLATED RAT HEPATOCYTE [J].

POUNDS, JG ;

WRIGHT, R ;

MORRISON, D ;

CASCIANO, DA .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1982, 63 (03) :389-401

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