Interferon-alpha 2a for chronic hepatitis B with e antigen or antibody: Comparable antiviral effects on wild-type virus and precore mutant

被引：20

作者：

Aikawa, T

Kanai, K

Kako, M

Kawasaki, T

Hino, K

Iwabuchi, S

Tsubouchi, H

Takehira, Y

Tsuda, F

Okamoto, H

Miyakawa, Y

Mayumi, M

机构：

[1] JICHI MED SCH, DIV IMMUNOL, MINAMI KAWACHI, TOCHIGI 32904, JAPAN

[2] AIKAWA INTERNAL HOSP, AIKAWA, IBARAKI, JAPAN

[3] TOSHIBA GEN HOSP, DEPT GASTROENTEROL, TOKYO, JAPAN

[4] TEIKYO UNIV HOSP, DEPT INTERNAL MED 4, MIZONOKUCHI, KANAGAWA, JAPAN

[5] HAMAMATSU UNIV SCH MED, DEPT INTERNAL MED 2, HAMAMATSU, SHIZUOKA, JAPAN

[6] NATL DEF MED COLL, DEPT INTERNAL MED 2, TOKOROZAWA, SAITAMA 359, JAPAN

[7] ST MARIANNA UNIV, SCH MED, DEPT INTERNAL MED 2, KAWASAKI, KANAGAWA 213, JAPAN

[8] MIYAZAKI MED COLL, DEPT INTERNAL MED 2, KIYOTAKE, MIYAZAKI, JAPAN

[9] HAMAMATSU MED CTR, DEPT GASTROENTEROL, HAMAMATSU, SHIZUOKA, JAPAN

[10] TOSHIBA GEN HOSP, DEPT MED SCI, TOKYO, JAPAN

来源：

JOURNAL OF VIRAL HEPATITIS | 1995年 / 2卷 / 05期

关键词：

hepatitis B; hepatitis B antibodies; hepatitis B e antigens; hepatitis B virus; interferons;

D O I：

10.1111/j.1365-2893.1995.tb00036.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Recombinant interferon-alpha 2a (IFN-alpha 2a) in a total dose of 702 MU was given to 31 patients: nine with wild-type hepatitis B virus (HBV) and hepatitis B e antigen (HBeAg) (A); four with HBeAg and a mixed infection with wild-type HBV and precore mutants (B); 11 with antibody to HBeAg (HBeAb) and a mixed infection (C); and seven with HBeAb and precore mutants alone (D). HBV DNA was not cleared in any patient in groups A and B. By contrast, in patients with HBeAb, HBV DNA was ultimately lost in four patients in group C, as well as in 10 patients in group D. Thus, patients with HBeAb and infected with precore mutants alone (D) lost serum HBV DNA more often than those with HBeAg and wild-type HBV (A), Patients with low pretreatment levels of HBV DNA cleared virus more frequently, and the response of precore mutant to IFN was comparable with that of wild-type HBV in patients who had a mixed infection. Based on these results, precore mutants do respond to IFN, and therefore, IFN is indicated in patients with HBeAb, especially those with low serum HBV DNA levels.

引用

页码：243 / 250

页数：8

共 32 条

[1] CHRONIC ACTIVE HEPATITIS WITH HEPATITIS-B VIRUS-DNA AND ANTIBODY AGAINST E-ANTIGEN IN THE SERUM - DISTURBED SYNTHESIS AND SECRETION OF E-ANTIGEN FROM HEPATOCYTES DUE TO A POINT MUTATION IN THE PRECORE REGION [J].