FORCED SWIM STRESS - SUPERSENSITIVITY OF THE ISOLATED RAT PACEMAKER TO THE CHRONOTROPIC EFFECT OF ISOPRENALINE AND THE ROLE OF CORTICOSTERONE

被引：11
作者：
MOURA, MJCS
DEMORAES, S
机构：
[1] UNIV SAO PAULO,INST BIOMED SCI,DEPT PHARMACOL,BR-05508900 SAO PAULO,BRAZIL
[2] PONTIFICIA UNIV CATOLICA CAMPINAS,SCH MED,DEPT PHYSIOL,CAMPINAS,SP,BRAZIL
来源：
GENERAL PHARMACOLOGY | 1994年 / 25卷 / 07期
关键词：
ISOLATED PACEMAKER; STRESS; SUPERSENSITIVITY; ISOPRENALINE; CORTICOSTERONE;
D O I：
10.1016/0306-3623(94)90157-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. Forced swim (three daily sessions) resulted in an increased plasma corticosterone level and supersensitivity of the isolated rat pacemaker to the chronotropic effect of isoprenaline. 2. Bilateral adrenalectomy, performed 2 days before forced swim, abolished the development of pacemaker supersensitivity to isoprenaline. 3. Administration to rats of the antiglucorticoid compound RU-38486 prevented the development of pacemaker supersensitivity to isoprenaline. Pretreatment of rats not submitted to forced swim with the synthetic glucocorticoid RU-28362 causes pacemaker supersensitivity to isoprenaline. 4. Pretreatment of rats with diazepam or imipramine which block the forced swim-induced increase in the plasma level of corticosterone prevented the development of pacemaker supersensitivity to isoprenaline. 5. It is concluded that corticosterone plays a critical role in the modulation of the sensitivity to catecholamines of the pacemaker beta-adrenoceptors during adaptation to repeated stress.
引用
收藏
页码：1341 / 1347
页数：7
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