Hydrogen Sulfide and Hydrogen Sulfide-Synthesizing Enzymes Are Altered in a Case of Oral Adenoid Cystic Carcinoma

被引:12
|
作者
Dongsoo, Kim [1 ]
Chen, Jie [2 ]
Wei, Eric [2 ,3 ]
Ansari, Junaid [3 ]
Meram, Andrew [1 ]
Patel, Stavan [1 ]
Ghali, Ghali [1 ]
Kevil, Christopher [2 ]
Shackelford, Rodney E. [2 ]
机构
[1] Louisiana State Univ, Hlth Sci Ctr, Dept Oral & Maxillofacial Head & Neck Surg, Head & Neck Oncol Microvasc Reconstruct Surg, Shreveport, LA 71105 USA
[2] Louisiana State Univ Hlth Shreveport, Dept Pathol, 1501 Kings Highway, Shreveport, LA 71130 USA
[3] Louisiana State Univ Hlth Shreveport, Dept Mol & Cellular Physiol, Shreveport, LA USA
来源
CASE REPORTS IN ONCOLOGY | 2018年 / 11卷 / 02期
关键词
Hydrogen sulfide; Hydrogen sulfide-synthesizing enzymes; Oral adenoid cystic carcinoma;
D O I
10.1159/000492464
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Adenoid cystic carcinomas (ACC) constitute 1% of all head and neck malignancies and are very rare in the oral cavity. With <60 oral ACCs described, their pathobiology is incompletely understood. Here, we report a case of oral cavity ACC in a 54-year-old woman. Since recent studies have demonstrated that several human tumors overexpress the hydrogen sulfide (H2S)-synthesizing enzymes cystathionine-beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST), and also show dysregulated H2S levels, we examined these biomarkers in the oral ACC and compared the results to those of adjacent benign oral epithelium. Western blotting was used to compare the protein expression of CBS, CSE, 3-MST, nicotinamide phosphoribosyl transferase, and mitoNEET in ACC and adjacent benign oral mucosae. High-performance liquid chromatography was used to quantify the differences in tissue H2S concentrations between the two biopsy types. We found that all the proteins examined here were increased in the ACC compared to adjacent benign oral mucosae. Interestingly, H2S concentrations were decreased approximately 30% in ACC compared to benign mucosae. Thus, in one example of this rare tumor type, the enzymes that synthesize H2S are increased, while tissue H2S levels are lower than those found in adjacent benign oral mucosae. Although limited to a single rare tumor type, to our knowledge this is the second time H2S concentrations have been directly quantified inside a human tumor. Last, our results may indicate that alterations in H2S synthesis and metabolism may be important in the pathobiology of ACC. (C) 2018 The Author(s) Published by S. Karger AG, Basel
引用
收藏
页码:585 / 590
页数:6
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