PRELIMINARY MAPPING OF THE DELETED REGION OF CHROMOSOME-9 IN BLADDER-CANCER

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CAIRNS, P
SHAW, ME
KNOWLES, MA
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R73 [肿瘤学];
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100214 ;
摘要
Inactivation of a suppressor gene by deletion of chromosome 9 is a candidate initiating event in bladder carcinogenesis. We have used 13 polymorphic markers spanning the length of chromosome 9 in order to map the region of deletion in human bladder carcinomas. In the majority of tumors loss of heterozygosity was found at all informative sites along the chromosome, indicating deletion of the entire chromosome. Nine tumors had selective deletions of chromosome 9. Mapping of the deleted region in these tumors suggests that the target gene is located between D9S22 at 9q22 and D9S18 at 9p12-13.
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页码:1230 / 1232
页数:3
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[41]   Transcript mapping of the region of chromosome 20q that is deleted in myeloproliferative disorders [J].
Bench, AJ ;
Aldred, MA ;
Holloway, TL ;
Champion, KM ;
Gilbert, JGR ;
Humphray, SJ ;
Gwilliam, R ;
Deloukas, P ;
Bentley, DR ;
Nacheva, EP ;
Green, AR .
BRITISH JOURNAL OF HAEMATOLOGY, 1998, 102 (01) :156-156
[42]   ARTIFICIAL SWEETENERS AND HUMAN BLADDER-CANCER - PRELIMINARY-RESULTS [J].
HOOVER, RN ;
STRASSER, PH .
LANCET, 1980, 1 (8173) :837-840
[43]   PRELIMINARY-REPORT ON HETEROCHROMATIN VARIABILITY IN CHROMOSOME-1, CHROMOSOME-9 AND CHROMOSOME-16 IN A SARDINIAN POPULATION [J].
ASTE, A ;
CARDIA, S ;
MILIA, A ;
MAMELI, M .
CLINICAL GENETICS, 1983, 23 (03) :223-223
[44]   REGIONAL MAPPING OF GALT AND ACO1 WITHIN THE SHORT ARM OF CHROMOSOME-9 [J].
MOHANDAS, T ;
SPARKES, MC ;
SPARKES, RS .
CYTOGENETICS AND CELL GENETICS, 1982, 32 (1-4) :300-300
[45]   THE TUMOR-SUPPRESSOR GENE ON CHROMOSOME-9, BANDS P21-22 - MAPPING THE CRITICAL REGION WITH MICRODISSECTION PROBES [J].
BOHLANDER, SK ;
DREYLING, M ;
HAGOS, F ;
SVEEN, L ;
OLOPADE, OI ;
DIAZ, MO .
CYTOGENETICS AND CELL GENETICS, 1993, 64 (02) :108-109
[46]   Human bladder cancers and normal bladder mucosa present the same hot spot of heterozygous chromosome-9 deletion [J].
Baud, E ;
Catilina, P ;
Boiteux, JP ;
Bignon, YJ .
INTERNATIONAL JOURNAL OF CANCER, 1998, 77 (06) :821-824
[47]   REGIONAL MAPPING OF GALT WITHIN THE SHORT ARM OF CHROMOSOME-9 BY GENE DOSAGE STUDIES [J].
BRIVET, M ;
BAPTISTA, J ;
KADHOM, N ;
RETHORE, MO ;
SONI, T ;
LEMONNIER, A ;
GAUTIER, M .
CYTOGENETICS AND CELL GENETICS, 1987, 46 (1-4) :586-587
[48]   DETECTION OF NUMERICAL CHROMOSOME-ABERRATIONS IN BLADDER-CANCER BY INSITU HYBRIDIZATION [J].
HOPMAN, AHN ;
PODDIGHE, PJ ;
SMEETS, AWGB ;
MOESKER, O ;
BECK, JLM ;
VOOIJS, GP ;
RAMAEKERS, FCS .
AMERICAN JOURNAL OF PATHOLOGY, 1989, 135 (06) :1105-1117
[49]   HETEROGENEITY IN BLADDER-CANCER AS DETECTED BY CONVENTIONAL CHROMOSOME ANALYSIS AND INTERPHASE CYTOGENETICS [J].
SCHAPERS, R ;
SMEETS, W ;
HOPMAN, A ;
PAUWELS, R ;
GERAEDTS, J ;
RAMAEKERS, F .
CANCER GENETICS AND CYTOGENETICS, 1993, 70 (01) :56-61
[50]   LOSS OF GENES ON THE SHORT ARM OF CHROMOSOME-11 IN BLADDER-CANCER [J].
FEARON, ER ;
FEINBERG, AP ;
HAMILTON, SH ;
VOGELSTEIN, B .
NATURE, 1985, 318 (6044) :377-380