SUPPRESSION OF MIXED LYMPHOCYTE-REACTION BY PROGESTERONE AND ESTRADIOL-17-BETA

被引：14

作者：

KOBAYASHI, H ^{[1
]}

MORI, T ^{[1
]}

SUZUKI, A ^{[1
]}

NISHIMURA, T ^{[1
]}

NISHIMOTO, H ^{[1
]}

HARADA, M ^{[1
]}

机构：

[1] SHIONOGI RES LAB,OSAKA,JAPAN

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1979年 / 134卷 / 03期

关键词：

D O I：

10.1016/S0002-9378(16)33029-0

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The effects of estrone, estradiol-17β, estriol, testosterone, progesterone, and 20α-dihydroprogesterone on incorporation of 3H-thymidine into cultured lymphocytes from normal men and non-pregnant women in response to allogeneic stimulation was investigated with two-way mixed lymphocyte reactions (MLR). A dose-dependent reduction in the mean percent incorporation was observed in the range of progesterone concentration between 2 x 103 and 104 ng/ml with statistically significant differences from the control cultures. Estradiol-17β at 104 ng/ml produced a slight but significant inhibition of incorporation. No significant change in incorporation occurred with the other steroids tested. Since the suppressive property of progesterone in phytohemagglutinin-induced lymphocyte culture reported in our previous communication was reproduced by the present investigation in MLR, the possible role of progesterone in immunoregulation during pregnancy is emphasized as has been postulated previously.

引用

页码：255 / 259

页数：5

共 16 条

[1] DELTA5-3BETA-HYDROXYSTEROID DEHYDROGENASE-ACTIVITY IN RAT EMBRYOS ON DAYS 1 THROUGH 7 OF PREGNANCY [J].