HIGH-RESOLUTION MALDI-TOF MASS-SPECTRA OF 3 PROTEINS OBTAINED USING SPACE-VELOCITY CORRELATION FOCUSING

被引:21
作者
KING, TB [1 ]
COLBY, SM [1 ]
REILLY, JP [1 ]
机构
[1] INDIANA UNIV,DEPT CHEM,BLOOMINGTON,IN 47405
来源
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES | 1995年 / 145卷 / 1-2期
关键词
MALDI-TOF MASS SPECTRA; PROTEINS;
D O I
10.1016/0168-1176(95)04176-L
中图分类号
O64 [物理化学(理论化学)、化学物理学]; O56 [分子物理学、原子物理学];
学科分类号
070203 ; 070304 ; 081704 ; 1406 ;
摘要
Mass spectra of cytochrome-c, lysozyme and trypsinogen are recorded using a compact linear time-of-flight instrument with a matrix-assisted laser desorption/ionization source. Space-velocity correlation focusing is employed to reduce observed ion time-of-flight peak widths to nearly the limits established by each ion's isotope distribution. Mass resolution of up to 1700 is achieved. Evidence of metastable decay in the field-free flight region is also presented.
引用
收藏
页码:L1 / L7
页数:7
相关论文
共 46 条
[1]   MATRIX-ASSISTED LASER-DESORPTION IONIZATION MASS-SPECTROMETRY OF RESTRICTION ENZYME-DIGESTED PLASMID DNA USING AN ACTIVE NAFION SUBSTRATE [J].
BAI, J ;
LIU, YH ;
LUBMAN, DM ;
SIEMIENIAK, D .
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1994, 8 (09) :687-691
[2]  
Beavis R C, 1989, Rapid Commun Mass Spectrom, V3, P432, DOI 10.1002/rcm.1290031207
[3]  
Beavis R C, 1989, Rapid Commun Mass Spectrom, V3, P233, DOI 10.1002/rcm.1290030708
[4]   VELOCITY DISTRIBUTIONS OF INTACT HIGH MASS POLYPEPTIDE MOLECULE IONS PRODUCED BY MATRIX ASSISTED LASER DESORPTION [J].
BEAVIS, RC ;
CHAIT, BT .
CHEMICAL PHYSICS LETTERS, 1991, 181 (05) :479-484
[5]   RAPID, SENSITIVE ANALYSIS OF PROTEIN MIXTURES BY MASS-SPECTROMETRY [J].
BEAVIS, RC ;
CHAIT, BT .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) :6873-6877
[6]   ALPHA-CYANO-4-HYDROXYCINNAMIC ACID AS A MATRIX FOR MATRIX-ASSISTED LASER DESORPTION MASS-SPECTROMETRY [J].
BEAVIS, RC ;
CHAUDHARY, T ;
CHAIT, BT .
ORGANIC MASS SPECTROMETRY, 1992, 27 (02) :156-158
[7]   TRYPTIC MAPPING OF RECOMBINANT PROTEINS BY MATRIX-ASSISTED LASER-DESORPTION IONIZATION MASS-SPECTROMETRY [J].
BILLECI, TM ;
STULTS, JT .
ANALYTICAL CHEMISTRY, 1993, 65 (13) :1709-1716
[8]   ANALYTICAL APPLICATIONS OF MATRIX-ASSISTED LASER DESORPTION AND IONIZATION MASS-SPECTROMETRY [J].
BORNSEN, KO ;
SCHAR, M ;
GASSMANN, E ;
STEINER, V .
BIOLOGICAL MASS SPECTROMETRY, 1991, 20 (08) :471-478
[9]   HIGH-RESOLUTION TOF MASS-SPECTROMETRY .2. EXPERIMENTAL CONFIRMATION OF IMPULSE-FIELD FOCUSING THEORY [J].
BROWDER, JA ;
MILLER, RL ;
THOMAS, WA ;
SANZONE, G .
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES, 1981, 37 (01) :99-108
[10]   SUPPRESSION OF MATRIX IONS IN ULTRAVIOLET-LASER DESORPTION - SCANNING ELECTRON-MICROSCOPY AND RAMAN-SPECTROSCOPY OF THE SOLID SAMPLES [J].
CHAN, TWD ;
COLBURN, AW ;
DERRICK, PJ ;
GARDINER, DJ ;
BOWDEN, M .
ORGANIC MASS SPECTROMETRY, 1992, 27 (03) :188-194