TTF1 GENE-EXPRESSION IN HUMAN PROLIFERATING THYROID-DISEASES

被引：0
|
作者：
PERLINO, E
MAENZA, S
MARRA, E
CIAMPOLILLO, A
MARRA, GA
DEROBERTIS, O
GIORGINO, R
QUAGLIARIELLO, E
机构：
[1] UNIV BARI,DEPT BIOCHEM & MOLEC BIOL,BARI,ITALY
[2] UNIV BARI,INST MED ENDOCRINOL & METAB DIS,BARI,ITALY
[3] GB MORGAGNI L PIERANTONI HOSP,DIV GEN SURG,FORLI,ITALY
来源：
ONCOLOGY REPORTS | 1994年 / 1卷 / 06期
关键词：
THYROID TRANSCRIPTION FACTOR 1; GENE EXPRESSION; CARCINOMA; ADENOMA; MULTINODULAR GOITER;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
TTF1 mRNA expression in the thyroid gland from 30 patients with thyroid proliferating diseases and 4 healthy donors used as normal controls was investigated using Northern blot analysis. Six patients affected by malignant thyroid carcinomas and six patients with adenoma were examined; moreover 18 patients with non malignant proliferating disease such as multinodular goiters were investigated. Determination of TTF1 mRNA revealed a significant decrease of the steady state mRNA levels in carcinomas and adenomas as compared to normal tissues. On the contrary, in patients affected by multinodular goiters variations were observed that seemed not to be directly associated with the pathological conditions.
引用
收藏
页码：1097 / 1100
页数：4
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