EFFECTS OF ETHACRYNIC ACID AND FUROSEMIDE ON URINARY CALCIUM PHOSPHATE AND MAGNESIUM

被引：140
作者：
DUARTE, CG
机构：
[1] Department of Medicine, Veterans Administration Hospital, Washington, DC
[2] Department of Medicine, George Washington University School of Medicine, Washington, DC
来源：
METABOLISM-CLINICAL AND EXPERIMENTAL | 1968年 / 17卷 / 10期
关键词：
D O I：
10.1016/0026-0495(68)90151-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Experiments were performed in dogs to determine the effects of Ethacrynic Acid and Furosemide on the renal excretion of calcium, magnesium and phosphate. Both diuretics had a similar action increasing calcium and magnesium excretion, while urinary phosphate remained constant. Plasma concentrations of calcium and magnesium decreased and phosphate rose but no appreciable change occurred when the urinary losses were replaced. Clearance of ultrafilterable calcium paralleled sodium clearance and increased in a greater proportion. A good correlation was found for sodium as related to calcium thus supporting the possibility of a relationship in the renal transport of these two ions. The clearance of ultrafilterable magnesium exceeded the clearance of inulin in some instances demonstrating a secretory mechanism for magnesium. © 1968.
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页码：867 / &
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