IMPROVED CARDIAC-PERFORMANCE WITH HUMAN CALCITONIN GENE RELATED PEPTIDE IN PATIENTS WITH CONGESTIVE HEART-FAILURE

被引：76
作者：
GENNARI, C
NAMI, R
AGNUSDEI, D
FISCHER, JA
机构：
[1] UNIV ZURICH,DEPT ORTHOPAED SURG,CALCIUM METAB RES LAB,FORCHSTR 340,CH-8008 ZURICH,SWITZERLAND
[2] UNIV ZURICH,DEPT MED,CH-8008 ZURICH,SWITZERLAND
[3] UNIV SIENA,I-53100 SIENA,ITALY
来源：
CARDIOVASCULAR RESEARCH | 1990年 / 24卷 / 03期
关键词：
Calcitonin gene related peptide; Contractility; Heart failure;
D O I：
10.1093/cvr/24.3.239
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Study objective - The aim of the study was to assess the cardiovascular effects of human calcitonin gene related peptide (CGRP) in patients with congestive heart failure.Design - The effects of CGRP II (or β), 12.5 μg·h-1, given by intravenous infusion for 24 h to digitalised patients with congestive heart failure, were assessed by measurement of cardiac functional indices.Patients - Five patients (four female) were studied. Age was 73-82 years. Three were in New York Heart Association phase III and two in phase IV.Measurements and main results - The pre-ejection period to left ventricular ejection time ratio and the QT distance adjusted for heart rate were lowered by 21% and 4% respectively. The left ventricular shortening index was raised by 43%. The arterial pressure and heart rate did not change consistently.Conclusion - Calcitonin gene related peptide improves myocardial contractility in patients with congestive heart failure. This is the first time this has been shown.
引用
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页码：239 / 241
页数：3
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