PHENYTOIN PHARMACOKINETICS IN YOUNG AND OLD ADULTS

被引：0

作者：

ESTRUCH, J ^{[1
]}

GALDAMES, D ^{[1
]}

MARTINETTI, A ^{[1
]}

SAAVEDRA, I ^{[1
]}

机构：

[1] UNIV CHILE,FAC MED,DEPT BIOQUIM,SANTIAGO,CHILE

来源：

REVISTA MEDICA DE CHILE | 1992年 / 120卷 / 10期

关键词：

PHENYTOIN; DRUG THERAPY; PHARMACOLOGY; CLINICAL; AGING;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To study the effect of old age on phenytoin pharmacokinetics, twelve young and nine old adults aged 21,7 +/- 1.8 and 71.8 +/- 4.9 years respectively, were studied. No significant differences of phenytoin indicating the drug distribution and elimination does not change with aging. After oral administration, significant differences were observed between young and old adults for absorption, measured through oral residence half time (36.89 +/- 5.07 h in young and 29.25 +/- 8.64 h in old adults p < 0. 05), absorption half time (6.91 +/- 3.6 vs 3.29 +/- 2.35 h) and maximal concentration (1.45 +/- 0.37 vs 2.0 +/- 0.79 ug/ml). However, absolute bioavailability of the drug was not different in both age groups (72.9 and 67.6% in young and old adults respectively). It is concluded that no modifications of phenytoin dosage are necessary in elderly people.

引用

页码：1106 / 1109

页数：4

共 7 条

[1] AGE AND PHENYTOIN KINETICS IN ADULT EPILEPTICS [J].