HLA-ANTIGEN FREQUENCIES AND WEGENERS GRANULOMATOSIS

被引：23

作者：

MURTY, GE

MAINS, BT

MIDDLETON, D

MAXWELL, AP

SAVAGE, DA

机构：

[1] FREEMAN RD HOSP,DEPT EAR NOSE & THROAT,NEWCASTLE TYNE NE7 7DN,TYNE & WEAR,ENGLAND

[2] ROYAL VICTORIA HOSP,DEPT EAR NOSE & THROAT,BELFAST BT12 6BA,NORTH IRELAND

[3] BELFAST CITY HOSP,CHILD PSYCHIAT LAB,BELFAST BT9 7AD,ANTRIM,NORTH IRELAND

[4] BELFAST CITY HOSP,DEPT NEPHROL,BELFAST BT9 7AD,ANTRIM,NORTH IRELAND

来源：

CLINICAL OTOLARYNGOLOGY | 1991年 / 16卷 / 05期

关键词：

WEGENERS GRANULOMATOSIS; HLA TISSUE TYPE; RESTRICTION FRAGMENT-LENGTH POLYMORPHISM;

D O I：

10.1111/j.1365-2273.1991.tb01037.x

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Previous reports of an association between HLA tissue type and Wegener's granulomatosis are contradictory. By using for the first time a highly sensitive restriction fragment-length polymorphism (RFLP) analysis in addition to standard microcytotoxicity assays, the largest series yet investigated (41 patients) was tissue typed. No association was found between any specific HLA antigen and Wegener's granulomatosis. Although the condition appears to be immunologically mediated, this study indicates that the HLA antigens do not have a major role.

引用

页码：448 / 451

页数：4

共 27 条

[1] WEGENER GRANULOMATOSIS - CLINICAL-PATHOLOGIC CORRELATIONS AND LONG-TERM COURSE [J].