RECANALIZATION CHARACTERISTICS OF INTRACORONARY STREPTOKINASE COMPARED TO INTRAVENOUS TISSUE-PLASMINOGEN ACTIVATOR FOLLOWING ACUTE MYOCARDIAL-INFARCTION - A COMMUNITY-HOSPITAL EXPERIENCE

被引:0
作者
RAMOS, RS [1 ]
SALEM, BI [1 ]
GOWDA, S [1 ]
HAIKAL, M [1 ]
COORDES, C [1 ]
LEIDENFROST, R [1 ]
机构
[1] ST LUKES HOSP, DIV CARDIOL, ST LOUIS, MO USA
关键词
D O I
10.1097/00007611-199509000-00012
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study compares the recanalization characteristics of intracoronary streptokinase (IC-SK) with those of intravenous tissue plasminogen activator (t-PA) in patients with acute myocardial infarction (AMI) treated in the first 6 hours after onset of symptoms. We studied 263 patients with AMI. Among these, 160 were treated with IC-SK; in 59 the drug was given within the first 3 hours and in 101 from 3 to 6 hours. Another 103 patients were treated with IV t-PA; in 64 the drug was given in the first 3 hours and in 39 within 3 to 6 hours. The recanalization rate in the IC-SK group at 0 to 3 hours was 73% and at 3 to 6 hours was 71%, with an overall recanalization rate of 72% from 0 to 6 hours. In the t-PA group, the recanalization rate at 0 to 3 hours was 72% and at 3 to 6 hours was 46%, with an overall recanalization rate of 62%. We conclude that during the first 6 hours of AMI, IC-SK treatment resulted in a rather steady thrombolysis rate, while t-PA treatment with the standard regimen produced a significant decline in recanalization when administered after 3 hours from the onset of AMI symptoms.
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页码:947 / 952
页数:6
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