SYSTEMIC LUPUS-ERYTHEMATOSUS ASSOCIATED WITH USE OF VALPROATE

被引：19

作者：

ASCONAPE, JJ ^{[1
]}

MANNING, KR ^{[1
]}

LANCMAN, ME ^{[1
]}

机构：

[1] WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT INTERNAL MED,WINSTON SALEM,NC 27103

来源：

EPILEPSIA | 1994年 / 35卷 / 01期

关键词：

ANTICONVULSANTS; VALPROATE; DRUG TOXICITY; SYSTEMIC LUPUS ERYTHEMATOSUS;

D O I：

10.1111/j.1528-1157.1994.tb02927.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 30-year-old man with long-standing localization-related epilepsy and mental retardation had seizures that were partially controlled with valproate (VPA) 500 mg four times daily. Routine examination showed severe thrombocytopenia with mild leukopenia and chronic low-grade hemolytic anemia. Pertinent laboratory results included positive ANA, rheumatoid factor, anti-NIA, circulating immune complexes, and antihistone antibody.The patient was treated with high dosage prednisone with partial improvement, but continued to have exacerbations at lower dosages. Fourteen months later, VPA was discontinued, and rapid improvement ensued. Prednisone was subsequently discontinued, and the patient has now maintained normal platelet counts for 18 months.

引用

页码：162 / 163

页数：2