BIOLOGICAL-ACTIVITIES OF CELL-ENVELOPE FRAGMENTS OF THE ARCHAEOBACTERIUM SULFOLOBUS-SOLFATARICUS - LETHAL TOXICITY, LOCAL HYPERSENSITIVITY, PYROGENICITY AND SPLEEN LYMPHOCYTE MITOGENICITY

被引：2

作者：

GALDIERO, F ^{[1
]}

SOMMESE, L ^{[1
]}

MARCATILI, A ^{[1
]}

SCARFOGLIERO, P ^{[1
]}

CAPASSO, C ^{[1
]}

MORANA, A ^{[1
]}

GALDIERO, M ^{[1
]}

机构：

[1] UNIV NAPOLI 2,FAC MED & CHIRURG,IST BIOCHIM MACROMOLEC,I-80138 NAPLES,ITALY

来源：

JOURNAL OF GENERAL MICROBIOLOGY | 1993年 / 139卷

关键词：

D O I：

10.1099/00221287-139-9-2167

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The sensitizing effect and the local and general toxicity related to membrane components of the archaeobacterium Sulfolobus solfataricus was studied. Cell envelope fragments were biologically active but this activity was lost upon separation of the lipid and protein components. The envelope fragments exerted lethal effects on mice sensitized with D-galactosamine that were prevented by pretreatment with anti-TNF-alpha serum. This lethal activity occurred in both LPS-responder (BALB/cByJ) and LPS-nonresponder (C3H/HeJ) mouse strains. In addition, Sulfolobus envelope fragments tested in rabbits caused a local Shwartzman reaction, and showed pyrogenic activity. In vitro, the envelope fragments that act on spleen lymphocytes of the LPS-responder (BALB/cByJ) and LPS-nonresponder (C3H/HeJ) mice caused an uptake of [H-3]thymidine similar to that caused by concanavalin A. A similar toxic activity to that exerted by eubacteria is therefore exerted by this non-pathogenic archaeobacterium despite the difference in surface chemistry.

引用

页码：2167 / 2172

页数：6

共 32 条

[1] SULFOLOBUS - NEW GENUS OF SULFUR-OXIDIZING BACTERIA LIVING AT LOW PH AND HIGH-TEMPERATURE [J].

BROCK, TD ;

BROCK, KM ;

BELLY, RT ;

WEISS, RL .

ARCHIV FUR MIKROBIOLOGIE, 1972, 84 (01) :54-&

[2]

BROCK TD, 1978, THERMOPHILIC MICROOR, P117

[3]

Buetler B., 1985, SCIENCE, V229, P869

[4] INTRAVENOUS USE OF FAT FOR TOTAL PARENTERAL NUTRITION OF INFANT [J].

CORAN, AG .

LIPIDS, 1972, 7 (07) :455-&

[5] THE LIPIDS OF ARCHAEBACTERIA [J].

DEROSA, M ;

GAMBACORTA, A .

PROGRESS IN LIPID RESEARCH, 1988, 27 (03) :153-175

[6] COLORIMETRIC METHOD FOR DETERMINATION OF SUGARS AND RELATED SUBSTANCES [J].

DUBOIS, M ;

GILLES, KA ;

HAMILTON, JK ;

REBERS, PA ;

SMITH, F .

ANALYTICAL CHEMISTRY, 1956, 28 (03) :350-356

[7] INDUCTION OF TOLERANCE TO LIPOPOLYSACCHARIDE (LPS)-D-GALACTOSAMINE LETHALITY BY PRETREATMENT WITH LPS IS MEDIATED BY MACROPHAGES [J].

FREUDENBERG, MA ;

GALANOS, C .

INFECTION AND IMMUNITY, 1988, 56 (05) :1352-1357

[8] REQUIREMENT FOR LIPOPOLYSACCHARIDE-RESPONSIVE MACROPHAGES IN GALACTOSAMINE-INDUCED SENSITIZATION TO ENDOTOXIN [J].

FREUDENBERG, MA ;

KEPPLER, D ;

GALANOS, C .

INFECTION AND IMMUNITY, 1986, 51 (03) :891-895

[9] TUMOR-NECROSIS-FACTOR-ALPHA MEDIATES LETHAL ACTIVITY OF KILLED GRAM-NEGATIVE AND GRAM-POSITIVE BACTERIA IN D-GALACTOSAMINE-TREATED MICE [J].

FREUDENBERG, MA ;

GALANOS, C .

INFECTION AND IMMUNITY, 1991, 59 (06) :2110-2115

[10] GALACTOSAMINE-INDUCED SENSITIZATION TO THE LETHAL EFFECTS OF ENDOTOXIN [J].

GALANOS, C ;

FREUDENBERG, MA ;

REUTTER, W .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (11) :5939-5943

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