THE EFFECT OF N-ACETYLCYSTEINE ON THE IN-VITRO GROWTH OF NORMAL RABBIT MIDDLE-EAR FIBROBLASTS

被引：8

作者：

OVESEN, T ^{[1
]}

GAIHEDE, M ^{[1
]}

LEDET, T ^{[1
]}

机构：

[1] AARHUS UNIV HOSP,BIOCHEM PATHOL RES LAB,DK-8000 AARHUS,DENMARK

来源：

CLINICAL OTOLARYNGOLOGY | 1993年 / 18卷 / 05期

关键词：

N-ACETYLCYSTEINE; MIDDLE EAR FIBROBLAST CULTURE; SECRETORY OTITIS MEDIA;

D O I：

10.1111/j.1365-2273.1993.tb00601.x

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

In the present study the effect of N-acetylcysteine on the growth pattern and collagen synthesis of cultures of rabbit middle ear fibroblasts was determined. The growth pattern was evaluated by cell counting, measurements of the total content of cell protein and mitotic activity by incorporation of H-3-thymidine. Collagen synthesis was estimated by incorporation of H-3-proline. The results demonstrate a dose-dependent reduction in both normal cell proliferation and collagen production. Thus, N-acetylcysteine seems to possess properties desirable and useful in the treatment of secretory otitis media.

引用

页码：400 / 405

页数：6

共 21 条

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