LITHIUM TREATMENT BLOCKS LONG-TERM SYNAPTIC DEPRESSION IN THE STRIATUM

被引：39
作者：
CALABRESI, P
PISANI, A
MERCURI, NB
BERNARDI, G
机构：
[1] Clinica Neurologica Dipartimento Sanità Università di Roma Tor Vergata, 00173 Rome, Via O. Raimondo
来源：
NEURON | 1993年 / 10卷 / 05期
关键词：
D O I：
10.1016/0896-6273(93)90210-I
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We have studied the effect of acute and chronic lithium treatment on the activity of striatal neurons recorded from corticostriatal slices. Under control conditions, tetanic stimulation of glutamatergic corticostriatal terminals caused long-term depression (LTD) of excitatory synaptic potentials. Acute lithium treatment did not affect the peak of the induction phase, but it reduced the following phases of LTD. LTD was completely blocked in slices obtained from rats chronically injected with LiCl. Lithium treatment failed to affect the intrinsic membrane properties of striatal neurons and the presynaptic inhibitory effects of carbachol and t-ACPD. We suggest that the lithium-induced blockade of LTD may contribute to the therapeutic action of lithium salts in mania and depression.
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收藏
页码：955 / 962
页数：8
相关论文
共 64 条
[31]   HALOPERIDOL-INDUCED PRESYNAPTIC DOPAMINE SUPER-SENSITIVITY IS BLOCKED BY CHRONIC LITHIUM [J].
GALLAGER, DW ;
PERT, A ;
BUNNEY, WE .
NATURE, 1978, 273 (5660) :309-312
[32]   PRESYNAPTIC LONG-TERM CHANGES IN EXCITABILITY OF THE CORTICOSTRIATAL PATHWAY [J].
GARCIAMUNOZ, M ;
YOUNG, SJ ;
GROVES, PM .
NEUROREPORT, 1992, 3 (04) :357-360
[33]   INFLUENCE OF LITHIUM ON DOPAMINE-STIMULATED ADENYLATE-CYCLASE ACTIVITY IN RAT-BRAIN [J].
GEISLER, A ;
KLYSNER, R .
LIFE SCIENCES, 1978, 23 (06) :635-636
[34]   ACUTE EFFECTS OF LITHIUM ON DOPAMINERGIC RESPONSES - IONTOPHORETIC STUDIES IN THE RAT VISUAL-CORTEX [J].
GOTTBERG, E ;
MONTREUIL, B ;
READER, TA .
SYNAPSE, 1988, 2 (04) :442-449
[35]   NEUROTRANSMITTERS AND NEUROMODULATORS IN THE BASAL GANGLIA [J].
GRAYBIEL, AM .
TRENDS IN NEUROSCIENCES, 1990, 13 (07) :244-254
[36]   A THEORY OF THE FUNCTIONAL-ORGANIZATION OF THE NEOSTRIATUM AND THE NEOSTRIATAL CONTROL OF VOLUNTARY MOVEMENT [J].
GROVES, PM .
BRAIN RESEARCH REVIEWS, 1983, 5 (02) :109-132
[37]  
HIRSCH JC, 1990, J PHYSL, V432, P123
[38]   CLIMBING FIBER INDUCED DEPRESSION OF BOTH MOSSY FIBER RESPONSIVENESS AND GLUTAMATE SENSITIVITY OF CEREBELLAR PURKINJE-CELLS [J].
ITO, M ;
SAKURAI, M ;
TONGROACH, P .
JOURNAL OF PHYSIOLOGY-LONDON, 1982, 324 (MAR) :113-134
[39]   LONG-TERM DEPRESSION [J].
ITO, M .
ANNUAL REVIEW OF NEUROSCIENCE, 1989, 12 :85-102
[40]   DOPAMINE-RECEPTORS IN THE CAUDATE-NUCLEUS AND MEMORY PROCESSES [J].
IZQUIERDO, I .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (01) :7-8
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