Massive Ingestion of Clopidogrel in a Suicidal Attempt: A Case Report and Review of Literature

被引:0
作者
Yilmaz, Fevzi [1 ]
Ciftci, Orcun [2 ]
Karakilic, Muhammed Evvah [1 ]
Kavalci, Cemil [3 ]
Arslan, Engin Deniz [1 ]
机构
[1] Ankara Numune Training & Res Hosp, Dept Emergency Med, TR-06100 Ankara, Turkey
[2] Baskent Univ, Dept Cardiol, Fac Med, Ankara, Turkey
[3] Baskent Univ, Dept Emergency Med, Fac Med, Ankara, Turkey
关键词
Clopidogrel; bleeding; overdose; suicide;
D O I
10.5152/jaem.2013.046
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Clopidogrel is an antiplatelet agent mainly used in coronary artery disease. It has a rare toxicity due to low side effect profile. In this paper we present a 55-year-old male patient presenting to the emergency department due to a clopidogrel overdose of 4200 mg in a suicidal attempt. He had no major or life-threatening hemorrhage, but hematuria that regressed spontaneously without a significant hemoglobin drop. He was monitored at the emergency department for 48 hours and discharged after an uneventful clinical course. There are limited reports about clopidogrel overdose in the literature. Although major systemic side effects such as major bleeding, purpura, heart failure, and other effects are known to occur with clopidogrel overdose, our patient did not experience such effects.
引用
收藏
页码:167 / 169
页数:3
相关论文
共 9 条
[1]   Pulmonary Haemorrhage and Haemothorax After Massive Ingestion of Clopidogrel as a Suicide Attempt [J].
Borderias Clau, Luis ;
Garrapiz Lopez, Javier ;
Caballero, Gonzalo .
ARCHIVOS DE BRONCONEUMOLOGIA, 2009, 45 (11) :570-571
[2]   Clopidogrel [J].
Coukell, AJ ;
Markham, A .
DRUGS, 1997, 54 (05) :745-750
[3]   Pattern of clopidogrel exposures reported to Texas poison centers during 1998-2004 [J].
Forrester, Mathias B. .
CLINICAL TOXICOLOGY, 2007, 45 (08) :950-955
[4]   A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE) [J].
Gent, M ;
Beaumont, D ;
Blanchard, J ;
Bousser, MG ;
Coffman, J ;
Easton, JD ;
Hampton, JR ;
Harker, LA ;
Janzon, L ;
Kusmierek, JJE ;
Panak, E ;
Roberts, RS ;
Shannon, JS ;
Sicurella, J ;
Tognoni, G ;
Topol, EJ ;
Verstraete, M ;
Warlow, C .
LANCET, 1996, 348 (9038) :1329-1339
[5]  
Huber K, 2012, ADV CARDIOL, V47, P31, DOI 10.1159/000338051
[6]   Suicide attempt with clopidogrel [J].
Kocabay, G. ;
Okcular, I. ;
Akkaya, V. ;
Guler, Kerim .
HUMAN & EXPERIMENTAL TOXICOLOGY, 2006, 25 (12) :731-734
[7]   Reversal of Thienopyridine-Induced Platelet Dysfunction Following Desmopressin Administration [J].
Levine M. ;
Swenson S. ;
McCormick T. ;
Henderson S.O. ;
Thomas S.H. ;
Markland F.S. .
Journal of Medical Toxicology, 2013, 9 (2) :139-143
[8]   Reversal of Clopidogrel-Induced Bleeding with rFVIIa in Healthy Subjects: A Randomized, Placebo-Controlled, Double-Blind, Exploratory Study [J].
Skolnick, Brett E. ;
Shenouda, Magdy ;
Khutoryansky, Naum M. ;
Pusateri, Anthony E. ;
Gabriel, Don ;
Carr, Marcus E. .
ANESTHESIA AND ANALGESIA, 2011, 113 (04) :703-710
[9]  
Yusuf S, 2001, NEW ENGL J MED, V345, P494