REGULATION OF DOPAMINE-D(2) RECEPTOR MESSENGER-RNA EXPRESSION IN THE OLFACTORY TUBERCLE BY COCAINE

被引：13
作者：
SPYRAKI, C
SEALFON, SC
机构：
[1] CUNY MT SINAI SCH MED, FISHBERG RES CTR NEUROBIOL, NEUROBIOL BOX 1065, 1 GUSTAVE L LEVY PL, NEW YORK, NY 10029 USA
[2] CUNY MT SINAI SCH MED, DEPT NEUROL, NEW YORK, NY 10029 USA
[3] UNIV CRETE, SCH MED, DEPT BASIC SCI, PHARMACOL LAB, IRAKLION, GREECE
来源：
MOLECULAR BRAIN RESEARCH | 1993年 / 19卷 / 04期
关键词：
COCAINE; DOPAMINE RECEPTOR; IN-SITU HYBRIDIZATION; STRIATUM; NUCLEUS ACCUMBENS; OLFACTORY TUBERCLE;
D O I：
10.1016/0169-328X(93)90131-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The influence of acute and chronic cocaine treatment on the expression of dopamine D2 receptor (D2R) mRNA was examined in the rat basal ganglia by in situ hybridization histochemistry. No significant alterations in D2R mRNA levels were observed in the striatum or the nucleus accumbens following acute or chronic cocaine. In the olfactory tubercle, acute cocaine (20 and 40 mg/kg, i.p.) was found to decrease D2R mRNA expression. Chronic cocaine (20 mg/kg, i.p. x 15 days), however, produced an increase in D2R mRNA levels in this region which was detected 24 h, but not 7 days after withdrawal. Acute and chronic cocaine have different effects on the regulation of D2R gene expression in the olfactory tubercle.
引用
收藏
页码：313 / 317
页数：5
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