Influence Of Disaggregation Effects Of Blood Vessels On Erythrocytes In Patients With Impaired Glucose Tolerance And Abdominal Obesity

The wide prevalence of thrombosis in patients with abdominal obesity with impaired glucose tolerance is caused by the presence of vasopathy. Because of the high incidence of the combination of abdominal obesity and impaired glucose tolerance in the adult population of developed countries, it is of great interest to assess the status of this level of vascular control over the aggregation of the most numerous red blood cells - red blood cells. The aim of the work is to assess the level of disaggregation capacity of blood vessels in relation to erythrocytes in patients with abdominal obesity and impaired glucose tolerance. 39 patients with abdominal obesity with impaired glucose tolerance of the second adulthood were examined. Control is represented by 26 healthy people of the same age. The study uses biochemical, hematological and statistical methods of investigation. In patients, activation of lipid peroxidation processes, excess cholesterol in erythrocyte membranes and reduction in total phospholipids in them were found. High spontaneous aggregation of erythrocytes was also revealed in patients. In this case, all patients showed weakened vascular control over erythrocyte aggregation. The revealed depression of the disaggregating properties of blood vessels in relation to erythrocytes is a consequence of metabolic disturbances arising during abdominal obesity with violation of glucose tolerance, active lipid peroxidation. Patient-specific vasopathy dramatically increased their risk of thrombosis, which can often lead to disability and death.