TESTOSTERONE IMPROVES MAZE PERFORMANCE AND INDUCES DEVELOPMENT OF A MALE HIPPOCAMPUS IN FEMALES

被引：287

作者：

ROOF, RL

HAVENS, MD

机构：

[1] UNIV WYOMING,DEPT PSYCHOL,LARAMIE,WY 82071

[2] UNIV WYOMING,NEUROSCI PROGRAM,LARAMIE,WY 82071

来源：

BRAIN RESEARCH | 1992年 / 572卷 / 1-2期

关键词：

DENTATE GYRUS; SEXUAL DIMORPHISM; SPATIAL MEMORY; STEROID HORMONE; HIPPOCAMPAL FORMATION;

D O I：

10.1016/0006-8993(92)90491-Q

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In a combined behavioral and morphometric study, we observed a testosterone-related sexual dimorphism in the granule cell layer of the hippocampus of Sprague-Dawley rats that appears to be related to sex differences in spatial performance. This cell layer was larger and laterally asymmetrical in males. Neonatal testosterone treatment of females resulted in a more male-like hippocampus. These treated females also performed better than controls, and as well as males, on a spatial navigation task. In addition, a strong correlation between the size of granule cell layers and maze performace was detected.

引用

页码：310 / 313

页数：4

共 23 条

[1] GONADAL-HORMONES AND SEX-DIFFERENCES IN NON-REPRODUCTIVE BEHAVIORS IN RODENTS - ORGANIZATIONAL AND ACTIVATIONAL INFLUENCES [J].