GENETIC AND ANTIGENIC CHARACTERIZATION OF OUTER MEMBRANE PHOSPHOLIPASE A OF YERSINIA PSEUDOTUBERCULOSIS

被引：0
|
作者：
Tishchenko, N. M. [1 ]
Bakholdina, S. I. [1 ]
Portnyagina, O. Yu. [1 ]
Sofronova, O. N. [2 ]
Guzev, K. V. [1 ]
Rakin, A. V. [3 ]
Isaeva, M. P. [1 ,4 ]
机构：
[1] FEBRAS PIBOC FEBRAS, GB Elyakov Pacific Inst Bioorgan Chem, 159,100 Let Vladivostoku Prospect, Vladivostok 690022, Russia
[2] Ctr Hyg & Epidemiol Sakha Yakutia Republ Rospotre, Lab Extremely Dangerous Infect, Yakutsk 677027, Russia
[3] Max von Pettenkofer Inst Hyg & Med Microbiol, D-80336 Munich, Germany
[4] Far Eastern Fed Univ, Biomed Sch, Vladivostok 690950, Russia
来源：
YAKUT MEDICAL JOURNAL | 2012年 / 04期
关键词：
Yersinia pseudotuberculosis; phospholipase A; allelic polymorphism; antibodies;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The analysis of gene polymorphism of Y. pseudotuberculosis membrane-associated phospholipase A was carried out. The high conservation of this enzyme at the nucleotide and amino acid levels was revealed. Recombinant phospholipase A expressed in E. coli cells was used as an antigen to detect specific antibodies. Antibodies against this protein were detected in sera of patients with acute intestinal and secondary forms of pseudotuberculosis.
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页码：148 / 157
页数：10
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