SODIUM VALPROATE IN THE PROPHYLACTIC TREATMENT OF MIGRAINE - A DOUBLE-BLIND-STUDY VERSUS PLACEBO

被引：227

作者：

HERING, R ^{[1
]}

KURITZKY, A ^{[1
]}

机构：

[1] TEL AVIV UNIV,SACKLER SCH MED,TEL AVIV,ISRAEL

来源：

CEPHALALGIA | 1992年 / 12卷 / 02期

关键词：

CIRCADIAN RHYTHM; DEPALEPT; MIGRAINE; SODIUM VALPROATE;

D O I：

10.1046/j.1468-2982.1992.1202081.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The efficacy of sodium valproate (Depalept) versus placebo in the treatment of migraine was evaluated in a double-blind randomized cross-over study in twenty-nine patients. The patients were divided into two groups each of which was alternately given 400 mg of sodium valproate B.I.d or placebo for eight weeks and then crossed over for an additional eight weeks. Our results show that in 86.2% of the patients sodium valproate was effective in preventing migraine or reducing the frequency, severity and duration of the attacks. In general, the drug was well tolerated and proved to be an effective treatment in migraine.

引用

页码：81 / 84

页数：4

共 23 条

[1] SPREADING DEPRESSION IN THE OLFACTORY-BULB OF RATS - RELIABLE INITIATION AND BOUNDARIES OF PROPAGATION [J].