ACUTE DIETARY PCPA TREATMENT DECREASES THE K(D) OF BRAIN [H-3] 5-HT BINDING IN RAINBOW-TROUT, ONCORHYNCHUS-MYKISS, FED A HIGH-CARBOHYDRATE DIET

被引：2
作者：
JOHNSTON, WL
GLANVILLE, NT
机构：
[1] UNIV GUELPH,DEPT NUTR SCI,GUELPH N1G 2W1,ONTARIO,CANADA
[2] MCGILL UNIV,MONTREAL GEN HOSP,RES INST,DEPT NEUROL,MONTREAL H3G 1A4,QUEBEC,CANADA
来源：
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1994年 / 107卷 / 03期
基金：
加拿大自然科学与工程研究理事会;
关键词：
PCPA; H-3]5-HT BINDING; ONCORHYNCHUS-MYKISS; HIGH CARBOHYDRATE DIET;
D O I：
10.1016/1367-8280(94)90076-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two experiments were conducted to determine the effect of dietary PCPA on brain [H-3]5-HT binding in rainbow trout. [H-3]5-HT binding was quantitatively similar to that observed in mammalian species. Dietary treatment with PCPA had no effect on the B(max) of [H-3]5-HT binding in either experiment while the K(D) was decreased in Experiment 1. These results demonstrate that [H-3]5-HT binding affinity is increased following short term inhibition of 5-HT synthesis by PCPA in rainbow trout.
引用
收藏
页码：455 / 461
页数：7
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